Correlation of hepatitis B surface antigen expression with clinicopathological and biochemical parameters in liver biopsies: A comprehensive study

Table 5 The association of clinicopathological factors and hepatitis B surface antigen expression patterns with viral response and serological response

	HBeAg positive (n = 86)							HBeAg negative (n = 54)
Parameters	VR			SR				VR
	HR (95%CI)	P value1	P value2		HR (95%CI)	P value1	P value2	HR (95%CI)	P value2
Age (yr)	0.685 (0.228-2.055)	0.001	0.449		0.892 (0.301-2.644)	0.007	0.837	0.936 (0.460-1.904)	0.855
Gender: male vs female	0.581 (0.301-1.121)	0.72	0.105		0.516 (0.251-1.062)	0.79	0.072	2.410 (0.986-5.985)	0.054
HBV DNA (log10IU/mL)	0.782 (0.275-2.224)	0.003	0.645		0.707 (0.246-2.029)	0.40	0.519	0.620 (0.255-1.508)	0.292
HBsAg (log10IU/mL)	1.931 (0.757-4.923)	0.001	0.168		2.252 (0.878-5.773)	0.001	0.091	0.700 (0.294-1.669)	0.422
ALT ≥ 200 IU/L vs < 200 IU/L	0.992 (0.476-2.068)	0.90	0.982		1.037 (0.436-2.471)	0.018	0.934	0.854 (0.372-1.962)	0.710
INR	0.539 (0.271-1.072)	0.751	0.078		0.493 (0.222-1.092)	0.901	0.081	1.815 (0.791-4.161)	0.159
Platelets (× 103/μL)	0.619 (0.309-1.240)	0.194	0.176		0.538 (0.243-1.189)	0.389	0.125	0.925 (0.452-1.892)	0.831
HAI score ≥ 9 vs < 9	1.566 (0.692-3.546)	0.282	0.282		2.881 (1.170-7.094)	0.132	0.021	6.876 (2.219-21.309)	0.001
Fibrosis ≥ 4 vs < 4	1.245 (0.517-2.999)	0.021	0.625		1.079 (0.427-2.730)	0.092	0.872	0.833 (0.326-2.125)	0.702
p-HBsAg	3.178 (1.582-6.387)	0.001	0.001		3.990 (1.843-8.638)	0.001	0.001	1.089 (0.575-2.063)	0.793
SP1	0.899 (0.495-1.634)	0.001	0.727		3.760 (1.742-7.861)	0.001	0.531	0.959 (0.443-2.167)	0.990
SP2	0.727 (0.240-2.200)	0.001	0.573		0.721 (0.216-2.410)	0.001	0.595	0.996 (0.552-1.798)	0.990
Membranous expression	1.085 (0.513-2.294)	0.001	0.831		1.082 (0.472-2.482)	0.001	0.952	0.692 (0.246-1.944)	0.485

¹Univariate analysis.

²Cox regression analysis.

VR: Viral response; SR: Serological response; HR: Hazard ratio; CI: Confidence interval; p-HbsAg: Percentage of hepatitis B surface antigen expression; SP: Staining pattern; ALT: Alanine aminotransferase; INR: International normalized ratio; HAI: histologic activity index; HBsAg: Hepatitis B surface antigen; HBeAg: Hepatitis B e antigen.