Atezolizumab and bevacizumab as first line therapy in advanced hepatocellular carcinoma: Practical considerations in routine clinical practice

doi:10.4254/wjh.v13.i9.1132

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Sep 27, 2021 (publication date) through Apr 27, 2024

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Sep 27, 2021; 13(9): 1132-1142
Published online Sep 27, 2021. doi: 10.4254/wjh.v13.i9.1132

Table 1 Results of phase Ib GO30140 study

	Arm A	Arm F
	Atezolizumab and bevacizumab combination (n = 104), median follow up 12.4 mo	Atezolizumab and bevacizumab combination (n = 60), median follow up 6.6 mo	Atezolizumab monotherapy (n = 59), median follow up 6.7 mo
ORR, n (%)	37 (36)	12 (20)	10 (17)
CR, n (%)	12 (12)	1 (2)	3 (5)
DCR, n (%)	78 (75)	40 (67)	29 (49)
Median PFS, mo	7.4 (5.6-10.7)	5.6 (3.6-2.4)	3.4 (1.9-5.2)
HR (80%CI)	-	0.55 (0.40-0.74), P value (0.0108)
12 mo PFS (%)	38
12 mo OS (%)	63

ORR: Over all response rates; CR: Complete response; DCR: Disease control rate; PFS: Progression free survival; HR: Hazard ratio; OS: Overall survival.

Citation: Jain A, Chitturi S, Peters G, Yip D. Atezolizumab and bevacizumab as first line therapy in advanced hepatocellular carcinoma: Practical considerations in routine clinical practice. World J Hepatol 2021; 13(9): 1132-1142
URL: https://www.wjgnet.com/1948-5182/full/v13/i9/1132.htm
DOI: https://dx.doi.org/10.4254/wjh.v13.i9.1132