Bile acid indices as biomarkers for liver diseases I: Diagnostic markers

Table 3 Absolute concentrations of major bile acids in controls and patients

BA	Unamidated	G-BA	T-BA	Total
	mean ± SE, µmol/L
Controls
Unsulfated BA
LCA	0.000 ± 0.00	0.000 ± 0.00	0.000 ± 0.00	0.001 ± 0.00
UDCA	0.004 ± 0.00	0.033 ± 0.00	0.002 ± 0.00	0.038 ± 0.00
CDCA	0.003 ± 0.00	0.008 ± 0.00	0.002 ± 0.00	0.013 ± 0.00
DCA	0.022 ± 0.00	0.011 ± 0.00	0.002 ± 0.00	0.035 ± 0.00
HDCA	0.01 ± 0.00	0.00 ± 0.00	ND	0.007 ± 0.00
MDCA	0.060 ± 0.01	ND	ND	0.058 ± 0.01
CA	0.179 ± 0.03	0.067 ± 0.00	0.009 ± 0.00	0.255 ± 0.03
MCA	0.028 ± 0.00	0.287 ± 0.02	0.041 ± 0.00	0.356 ± 0.02
HCA	0.008 ± 0.00	0.016 ± 0.00	0.001 ± 0.00	0.026 ± 0.00
Other BA1	0.160 ± 0.01	-	-	0.160 ± 0.01
Total unsulfated	0.464 ± 0.04	0.422 ± 0.02	0.057 ± 0.00	0.943 ± 0.05
Sulfated BA
LCA	0.010 ± 0.00	0.780 ± 0.04	0.220 ± 0.01	1.010 ± 0.05
UDCA	0.450 ± 0.02	1.040 ± 0.05	0.030 ± 0.00	1.520 ± 0.07
CDCA	0.070 ± 0.01	2.380 ± 0.13	0.060 ± 0.00	2.510 ± 0.13
DCA	0.010 ± 0.00	2.900 ± 0.14	0.220 ± 0.02	3.130 ± 0.16
CA	0.004 ± 0.00	0.056 ± 0.01	0.126 ± 0.01	0.190 ± 0.01
Total sulfated	0.535 ± 0.03	7.170 ± 0.28	0.650 ± 0.03	8.350 ± 0.31
Overall total	1.000 ± 0.05	7.590 ± 0.29	0.710 ± 0.03	9.300 ± 0.33
Patients
Unsulfated BA
LCA	0.004 ± 0.00	0.001 ± 0.00	0.0001 ± 0.00	0.005 ± 0.00
UDCA	0.079 ± 0.03	0.410 ± 0.17	0.012 ± 0.00	0.500 ± 0.21
CDCA	0.020 ± 0.00	0.090 ± 0.01	0.100 ± 0.02	0.210 ± 0.03
DCA	0.040 ± 0.00	0.040 ± 0.00	0.010 ± 0.00	0.090 ± 0.01
HDCA	0.010 ± 0.00	0.00 ± 0.00	ND	0.010 ± 0.00
MDCA	0.050 ± 0.01	ND	ND	0.050 ± 0.01
CA	0.240 ± 0.03	0.550 ± 0.07	0.320 ± 0.08	1.120 ± 0.14
MCA	0.120 ± 0.02	1.940 ± 0.29	0.730 ± 0.09	2.790 ± 0.34
HCA	0.010 ± 0.00	0.170 ± 0.02	0.090 ± 0.02	0.270 ± 0.04
Other BA1	0.860 ± 0.13	-	-	0.860 ± 0.13
Total	0.460 ± 0.04	0.42 ± 0.02	0.06 ± 0.00	5.910 ± 0.57
Sulfated BA
LCA	0.030 ± 0.01	2.230 ± 0.20	0.650 ± 0.06	2.910 ± 0.24
UDCA	1.560 ± 0.23	15.30 ± 2.68	1.230 ± 0.27	18.10 ± 3.08
CDCA	0.190 ± 0.03	18.70 ± 1.79	1.910 ± 0.38	20.80 ± 2.07
DCA	0.040 ± 0.01	4.280 ± 0.54	0.520 ± 0.07	4.840 ± 0.58
CA	0.080 ± 0.01	0.910 ± 0.13	1.030 ± 0.21	2.010 ± 0.31
Total	1.900 ± 0.24	41.40 ± 4.12	5.340 ± 0.74	48.70 ± 4.77
Overall total	3.330 ± 0.33	44.60 ± 4.46	6.610 ± 0.85	54.60 ± 5.20

¹Other bile acids: Nor-deoxycholic acid, 12-oxo-chenodeoxycholic acid, 3-dehydrocholic acid, 6-oxo-lithocholic acid, 7-oxo-lithocholic acid, 12-oxo-lithocholic acid, isolithocholic acid, and isodeoxycholic acid.

ND: Not detected; -: Not quantified; BA: Bile acids; G: Glycine; T: Taurine; CDCA: Chenodeoxycholic acid; CA: Cholic acid; LCA: Lithocholic acid; UDCA: Ursodeoxycholic acid; DCA: Deoxycholic acid; HDCA: Hyodeoxycholic acid; MDCA: Murideoxycholic acid; MCA: Muricholic acid; HCA: Hyocholic acid.