Biliary complications in recipients of living donor liver transplantation: A single-centre study

Table 3 Risk factors for biliary strictures: Categorical factors

Variable		Biliary strictures		OR	CI		P value1
		No stricture (n = 109)	Stricture (n = 60)		95% LCL	95% UCL
		n, Row %	n, Row %
Etiology of cirrhosis	HCV	95 (64.2)	53 (35.8)				0.1422
	Isolated HBV	5 (100)	0 (0)
	Combined HCV & HBV	1 (25)	3 (75)
	Causes other than viral hepatitis	8 (66.7)	4 (33.3)
Donors’ gender	Male	90 (63.8)	51 (36.2)	0.8	0.4	2.0	0.684
	Female	19 (67.9)	9 (32.1)
Recipients’ gender	Male	96 (64)	54 (36)	0.8	0.3	2.3	0.704
	Female	13 (68.4)	6 (31.6)
HCV PCR viremia prior to transplantation	Negative	20 (60.6)	13 (39.4)				0.7683
	Below 200000 IU	41 (69.5)	18 (30.5)
	200000 to 2 million	44 (63.8)	25 (36.2)
	More than 2 million	4 (50)	4 (50)
Antiviral treatment prior to transplantation	-	92 (66.7)	46 (33.3)	1.6	0.7	3.6	0.214
	+	17 (54.8)	14 (45.2)
Hepatocellular carcinoma	-	71 (65.1)	38 (34.9)	1.1	0.6	2.1	0.815
	+	38 (63.3)	22 (36.7)
Arterial complications	-	102 (65.8)	53 (34.2)	1.9	0.6	5.8	0.2552
	+	7 (50)	7 (50)
Number of anastomoses	One	70 (64.2)	39 (35.8)				0.9103
	Two	37 (64.9)	20 (35.1)
	Three	2 (66.7)	1 (33.3)
Number of ducts	1 Duct	50 (64.1)	28 (35.9)				0.8573
	2 Ducts	52 (66.7)	26 (33.3)
	3 Ducts	6 (50)	6 (50)
	4 Ducts	1 (100)	0 (0)
Number of stents	Nil	5 (71.4)	2 (28.6)				0.5783
	1 Stent	43 (60.6)	28 (39.4)
	2 Stents	53 (67.1)	26 (32.9)
	3 Stents	7 (63.6)	4 (36.4)
	4 Stents	1 (100)	0 (0)
Immunosuppressant	Tacrolimus	81 (68.6)	37 (31.4)	1.8	0.9	3.5	0.087
	Cyclosporine	28 (54.9)	23 (45.1)
Biliary leakage	-	80 (70.2)	34 (29.8)	2.1	1.1	4.1	0.026
	+	29 (52.7)	26 (47.3)
Biliary infection	-	62 (86.1)	10 (13.9)	6.6	3.0	14.4	< 0.001
	+	47 (48.5)	50 (51.5)
Frequency of biliary infection	Nil	62 (86.1)	10 (13.9)				< 0.0013
	1-2 Episodes	45 (53.6)	39 (46.4)
	≥ 3 Episodes	2 (15.4)	11 (84.6)
Early biliary infection	-	64 (82.1)	14 (17.9)	4.7	2.3	9.5	< 0.001
	+	45 (49.5)	46 (50.5)
Chronic graft rejection	-	99 (69.7)	43 (30.3)	3.9	1.7	9.2	0.001
	+	10 (37)	17 (63)
Recurrent HCV	-	87 (68)	41 (32)	1.8	0.9	3.8	0.096
	+	22 (53.7)	19 (46.3)

¹Pearson chi-squared test unless otherwise indicated.

²Fisher’s exact test.

³Chi-squared test for trend.

Data are presented as number (n) and percentage (%). OR: Odds ratio; LCL: Lower confidence limit; UCL: Lower confidence limit. HCV: Hepatitis C virus; HBV: Hepatitis B virus; PCR: Polymerase chain reaction.