Gut dysbiosis and systemic inflammation promote cardiomyocyte abnormalities in an experimental model of steatohepatitis

Table 3 Correlation of gut microbiota at family level, steatohepatitis, and cardiovascular risk factors

Variable1 (Family)	Severity and progression of liver injury				CVR factors and metabolism of lipids
	NAFLD score	Quantification of collagen (picrosirius)	TIMP-1	MCP-1	miR-33a	miR-126	PAI-1	CRI-I	CRI-II	AC
Actinomycetaceae					0.5842
Aerococcaceae
Anaeroplasmataceae		-0.5532						-0.6142		-0.6142
Atopobiaceae	0.6272	0.6102						0.5922	0.6632	0.5922
Bacillales_unclassified						0.5492		-0.5482	-0.5332	-0.5482
Bacteroidaceae	0.8362	0.7462	0.7842		0.6892	-0.7542		0.6622	0.7322	0.6622
Bacteroidales_unclassified		-0.5602							-0.5892	-0.4922
Burkholderiaceae									0.5642
Clostridiaceae	0.8072	0.7232	0.6452		0.5932	-0.6692		0.6762	0.6382	0.6762
Clostridiales_unclassified	-0.6282	-0.5292	-0.5352		-0.5762				-0.5862	-0.5252
Clostridiales_vadinBB60	-0.6022	-0.6712	-0.5272		-0.5582	0.5242		-0.6262	-0.5022	-0.6262
Corynebacteriaceae	-0.6692	-0.5452	-0.6802		-0.7822	0.6112		-0.5712	-0.6222	-0.5712
Desulfovibrionaceae	-0.8062	-0.6032	-0.8722	-0.7762	-0.6312	0.7552		-0.7292	-0.7462	-0.7292
Eggerthellaceae									0.4902
Firmicutes_unclassified	-0.7972	-0.6372	-0.6872		-0.6552	0.5942		-0.6292	-0.6992	-0.6292
Gastranaerophilales	-0.8222	-0.6562	-0.6442		-0.6432	0.6572		-0.6982	-0.5862	-0.6982
Lachnospiraceae	-0.8502	-0.6532	-0.7892	-0.7882	-0.6132	0.7662		-0.6432	-0.6292	-0.6432
Lactobacillaceae	-0.6162	-0.6332				0.7952			-0.5292
Lactobacillales_unclassified
Micrococcaceae	0.6692		0.5342			-0.5282			0.4932
Mollicutes_RF39_fa	-0.6502	-0.6182	-0.5902		-0.6092	0.7132		-0.8572	-0.7682	-0.8572
Moraxellaceae	-0.6692	-0.5362	-0.5572		-0.5432			-0.5992	-0.4732	-0.5992
Muribaculaceae	-0.8162	-0.7942			-0.5762	0.6932	-0.6842	-0.8272	-0.8462	-0.8272
Pasteurellaceae
Prevotellaceae		-0.7052				0.6032			-0.5222	-0.4862
Rikenellaceae					-0.6792
Saccharimonadaceae	-0.7372	-0.5592	-0.6192		-0.6742	0.6562		-0.7762	-0.7592	-0.7762
Staphylococcaceae	-0.7342	-0.6472	-0.8082		-0.8382	0.7162		-0.6162	-0.6792	-0.6162
Streptococcaceae	0.7902	0.7262	0.6372		0.5952	-0.6222			0.7242	0.5152

¹Variables were evaluated by Spearman's r correlation coefficient, moderate (0.3 < r < 0.6) or strong (0.6 < r < 0.9).

²Correlation significant at the 0.05 level.

AC: Atherogenic coefficient; CRI: Castelli’s risk index; CVR: Cardiovascular risk; MCP: Monocyte chemoattractant protein; NAFLD: Nonalcoholic fatty liver disease; PAI: Plasminogen activator inhibitor; TIMP: Tissue inhibitor of metalloproteinase.