Gut dysbiosis and systemic inflammation promote cardiomyocyte abnormalities in an experimental model of steatohepatitis

doi:10.4254/wjh.v13.i12.2052

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Dec 27, 2021; 13(12): 2052-2070
Published online Dec 27, 2021. doi: 10.4254/wjh.v13.i12.2052

Table 3 Correlation of gut microbiota at family level, steatohepatitis, and cardiovascular risk factors

Variable¹ (Family)	Severity and progression of liver injury				CVR factors and metabolism of lipids
Variable¹ (Family)	NAFLD score	Quantification of collagen (picrosirius)	TIMP-1	MCP-1	miR-33a	miR-126	PAI-1	CRI-I	CRI-II	AC
Actinomycetaceae					0.584²
Aerococcaceae
Anaeroplasmataceae		-0.553²						-0.614²		-0.614²
Atopobiaceae	0.627²	0.610²						0.592²	0.663²	0.592²
Bacillales_unclassified						0.549²		-0.548²	-0.533²	-0.548²
Bacteroidaceae	0.836²	0.746²	0.784²		0.689²	-0.754²		0.662²	0.732²	0.662²
Bacteroidales_unclassified		-0.560²							-0.589²	-0.492²
Burkholderiaceae									0.564²
Clostridiaceae	0.807²	0.723²	0.645²		0.593²	-0.669²		0.676²	0.638²	0.676²
Clostridiales_unclassified	-0.628²	-0.529²	-0.535²		-0.576²				-0.586²	-0.525²
Clostridiales_vadinBB60	-0.602²	-0.671²	-0.527²		-0.558²	0.524²		-0.626²	-0.502²	-0.626²
Corynebacteriaceae	-0.669²	-0.545²	-0.680²		-0.782²	0.611²		-0.571²	-0.622²	-0.571²
Desulfovibrionaceae	-0.806²	-0.603²	-0.872²	-0.776²	-0.631²	0.755²		-0.729²	-0.746²	-0.729²
Eggerthellaceae									0.490²
Firmicutes_unclassified	-0.797²	-0.637²	-0.687²		-0.655²	0.594²		-0.629²	-0.699²	-0.629²
Gastranaerophilales	-0.822²	-0.656²	-0.644²		-0.643²	0.657²		-0.698²	-0.586²	-0.698²
Lachnospiraceae	-0.850²	-0.653²	-0.789²	-0.788²	-0.613²	0.766²		-0.643²	-0.629²	-0.643²
Lactobacillaceae	-0.616²	-0.633²				0.795²			-0.529²
Lactobacillales_unclassified
Micrococcaceae	0.669²		0.534²			-0.528²			0.493²
Mollicutes_RF39_fa	-0.650²	-0.618²	-0.590²		-0.609²	0.713²		-0.857²	-0.768²	-0.857²
Moraxellaceae	-0.669²	-0.536²	-0.557²		-0.543²			-0.599²	-0.473²	-0.599²
Muribaculaceae	-0.816²	-0.794²			-0.576²	0.693²	-0.684²	-0.827²	-0.846²	-0.827²
Pasteurellaceae
Prevotellaceae		-0.705²				0.603²			-0.522²	-0.486²
Rikenellaceae					-0.679²
Saccharimonadaceae	-0.737²	-0.559²	-0.619²		-0.674²	0.656²		-0.776²	-0.759²	-0.776²
Staphylococcaceae	-0.734²	-0.647²	-0.808²		-0.838²	0.716²		-0.616²	-0.679²	-0.616²
Streptococcaceae	0.790²	0.726²	0.637²		0.595²	-0.622²			0.724²	0.515²

¹Variables were evaluated by Spearman's r correlation coefficient, moderate (0.3 < r < 0.6) or strong (0.6 < r < 0.9).

²Correlation significant at the 0.05 level.

AC: Atherogenic coefficient; CRI: Castelli’s risk index; CVR: Cardiovascular risk; MCP: Monocyte chemoattractant protein; NAFLD: Nonalcoholic fatty liver disease; PAI: Plasminogen activator inhibitor; TIMP: Tissue inhibitor of metalloproteinase.

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Citation: Longo L, Rampelotto PH, Filippi-Chiela E, de Souza VEG, Salvati F, Cerski CT, da Silveira TR, Oliveira CP, Uribe-Cruz C, Álvares-da-Silva MR. Gut dysbiosis and systemic inflammation promote cardiomyocyte abnormalities in an experimental model of steatohepatitis. World J Hepatol 2021; 13(12): 2052-2070
URL: https://www.wjgnet.com/1948-5182/full/v13/i12/2052.htm
DOI: https://dx.doi.org/10.4254/wjh.v13.i12.2052

Longo L, Rampelotto PH, Filippi-Chiela E, de Souza VEG, Salvati F, Cerski CT, da Silveira TR, Oliveira CP, Uribe-Cruz C, Álvares-da-Silva MR. Gut dysbiosis and systemic inflammation promote cardiomyocyte abnormalities in an experimental model of steatohepatitis. World J Hepatol 2021; 13(12): 2052-2070 [PMID: 35070008 DOI: 10.4254/wjh.v13.i12.2052]

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