Genotype E: The neglected genotype of hepatitis B virus

Table 2 Comparison of the virological and clinical characteristics of genotype E with other genotypes

	Genotypes
	E	A	B	C	D	F	G	H
HBV DNA level	Increased	Decreased	Decreased	Increased	Not studied	Not studied	Not studied	Not studied
Frequency of precore G1896A mutation	Increased1	Decreased	Increased	Decreased	Increased	Not studied	Not studied	Not studied
Frequency of basic core promoter T1762A/A1764G mutation	Not studied	Increased	Decreased	Increased	Decreased	Not studied	Not studied	Not studied
Frequency of preS deletion mutation	Not studied	Increased	Decreased	Increased	Not studied	Not studied	Not studied	Not studied
Tendency of chronicity
High		+		+
Low			+		+
Not studied	+					+	+	+
HBeAg positivity
High	+			+
Low		+	+		+
Not studied						+	+	+
HBeAg seroconversion
Early		+	+
Late				+	+
Not studied	+					+	+	+
HBsAg seroconversion
More		+	+
Less				+	+
Not studied	+					+	+	+

¹Relative to D3.

+: Classification of category; preS: Surface protein; HBeAg: Hepatitis B e antigen; HBsAg: Hepatitis B surface antigen. Adapted from Yousif et al[53,54], Shimakawa et al[72] and Schaefer et al[82].