Do peripartum and postmenopausal women with primary liver cancer have a worse prognosis? A nationwide cohort in Taiwan

Table 5 Cox model measured hazard ratios and 95% confidence intervals of death associated with and without menopause primary liver cancer patients

Characteristics	Event, N = 9982	Person, yr	IR	Crude		Adjusted
				HR (95%CI)	P value	HR (95%CI)	P value
Liver cancer
≥ 50 yr	8279	23410	35.37	Ref.		Ref.
< 50 yr	1703	9149	18.61	0.65 (0.61-0.68)	< 0.001	0.64 (0.61-0.68)	< 0.001
Baseline comorbidity
HBV	2049	7552	27.13	0.81 (0.77-0.85)	< 0.001	0.76 (0.72-0.80)	< 0.001
HCV	831	3513	23.65	0.75 (0.70-0.81)	< 0.001	0.72 (0.67-0.78)	< 0.001
Unspecified chronic hepatitis	584	2224	26.25	0.90 (0.83-0.98)	0.015	0.96 (0.88-1.05)	0.349
Alcoholic liver disease	165	449	36.72	1.04 (0.89-1.21)	0.640	1.07 (0.91-1.25)	0.408
Cirrhosis	3186	9924	32.10	1.01 (0.97-1.05)	0.739	1.18 (1.13-1.24)	< 0.001
Biliary stone	955	2730	34.98	1.08 (1.01-1.15)	0.024	0.98 (0.91-1.05)	0.562
Cholecystitis	416	2162	19.25	0.70 (0.63-0.77)	< 0.001	0.71 (0.64-0.78)	< 0.001
Cholangitis	687	989	69.45	1.76 (1.63-1.91)	< 0.001	1.77 (1.63-1.92)	< 0.001

Adjusted HR: Adjusted for comorbidities in Cox proportional hazards regression; CI: Confidence interval; HR: Hazard ratios; HBV: Hepatitis B virus; HCV: Hepatitis C virus; IR: Incidence rate.