Health-related quality of life in autoimmune hepatitis

Table 2 Overview of the questionnaires assessing aspects of health-related quality of life in autoimmune hepatitis

Questionnaire	Main function	Domains	Items, total score
CFQ[41]	Cognition	Memory, attention, concentration, forgetfulness, word-finding abilities, and confusion	25 items scored 0-4, total score 0-100
CLDQ[42]	Generic HRQoL	Abdominal symptoms, fatigue, systemic symptoms, activity, emotions, and worry	29 items scored 1-7, total score 29-203
ECR[43]	Relationship styles	ECR-anxiety, and ECR-avoidance	12 items scored 1-7, each scale total score 7-42
EQ-5D-5L/EQ-5D-3L/EQ-VAS[44]	Generic HRQoL, EQ-VAS: participants’ self-rated health on a visual analog scale	Mobility, self-care, usual activities, pain/discomfort, and anxiety/depression	EQ-5D: 5 items scored 1-5, total score 5-25; EQ-VAS: total score 0-100
FACIT-F[45]	Fatigue	Physical well-being, social well-being, emotional well-being, functional well-being, and a fatigue-specific domain	40 items scored 0-4, total score 0-160
FIS[46]	Fatigue	Cognitive functioning, physical functioning, and psychosocial functioning	40 items scored 0-4, total score 0-160
GAD-7[47]	Anxiety	-	7 items scored 0-3, total score 0-21
HADS[48]	Anxiety, depression	Anxiety, and depression	14 items scored 0-3, total score 0-42
LDSI[49]	Liver disease symptoms	Itch, joint pain, abdominal pain, daytime sleepiness, worry about family situation, decreased appetite, depression, fear of complications, and jaundice (+ symptom hinderance)	18 items scored 1-5, total score 18-90
MFI-20[50]	Fatigue	General fatigue, physical fatigue, reduction in activity, reduction in motivation, and mental fatigue	20 items scored 1-5, each domain total score 4-20
MFIS[46,51]	Fatigue	Physical, cognitive, and psychosocial functioning	21 items scored 0-4, total score 0-84
PHQ-9[52]	Depression	Anhedonia, feeling down, sleep, feeling tired, appetite, feeling bad about self, concentration, activity, and suicidality	9 items scored 0-3, total score 0-27
SF-12[53]	Generic HRQoL	Physical functioning, role limitations due to physical problems, bodily pain, general health, vitality, social functioning, role limitations due to emotional problems, and mental health	12 items scored 1-5, total score 0-100
SF-36[54]	Generic HRQoL	General health, physical and social functioning, bodily pain, role-physical, mental health, role-emotional, and vitality	36 items, total score 0-100
STAI[55]	Anxiety	State anxiety, and trait anxiety	40 items scored 1-4, total score 0-80
WPAI:SHP[56]	Impairment in daily activities and in work	Work productivity impairment, and activity impairment	6 items scored 0-10, total score -

Included in the table are the questionnaires that were employed in the reviewed studies. CFQ: Cognitive Failure Questionnaire; CLDQ: Chronic Liver Disease Questionnaire; ECR^: Experiences in Close Relationship Scale; EQ-5D-5L/EQ-5D-3L/EQ-VAS: European Quality of life 5-Dimension 5-Level/3-Level/EQ-visual analog scale; FACIT-F^: Functional Assessment of Chronic Illness Therapy-Fatigue; FIS: Fatigue Impact Scale; GAD-7: Generalized Anxiety Disorder Screener; HADS: Hospital Anxiety Depression Scale; LDSI: Liver Disease Symptom Index 2.0); MFI-20: Multidimensional Fatigue Index-20; MFIS: Modified Fatigue Impact Scale); PHQ-9: Patient Health Questionnaire; SF-12: Short-form 12; SF-36: Short-form 36; STAI: State-Trait Anxiety Inventory; WPAI:SHP: Work Productivity and Activity-Specific Health Problem).