Transaminitis is an indicator of mortality in patients with COVID-19: A retrospective cohort study

Table 3 Characteristics of those with and without transaminitis

	Transaminitis (n = 73)	No transaminitis (n = 57)	P value
Age, yr, median (IQR)	63 (48, 72)	62 (48, 76)	0.9
Females	31 (42.5)	28 (49.1)	0.4
Body mass index, kg/m2, median (IQR)	30.2 (26.5, 36.8)	27.3 (24.5, 33.2)	0.04
Smoking	19 (26)	19 (33.3)	0.4
Alcohol	20 (27.4)	10 (17.5)	0.2
Diarrhea	24 (32.9)	10 (17.5)	0.05
Nausea	18 (24.7)	14 (24.6)	1.0
Abdominal pain	11 (15.1)	10 (17.5)	0.7
Anorexia	19 (26)	15 (26.3)	1.0
Other gastro-intestinal symptoms1	19 (26)	18 (31.6)	0.5
X-ray findings2	55 (75.3)	32 (56.1)	0.02
Hypertension	38 (52.1)	31 (54.4)	0.8
Age-adjusted Charlson Index, median (IQR)	3 (1, 6)	4 (1, 6)	0.7
On ventilator	31 (42.5)	12 (21.1)	0.01
Admitted to intensive care unit	39 (53.4)	19 (33.3)	0.02
On medications with GI side-effects	26 (35.6)	20 (35.1)	1.0
Alanine aminotransferase, IU/L, median (IQR)	48 (34, 84)	15 (10, 20)	< 0.001
Aspartate aminotransferase, IU/L, median (IQR)	66 (42, 100)	20 (14, 26)	< 0.001
Alkaline phosphatase, IU/L, median (IQR)	97 (66, 124)	70 (56, 92)	< 0.001
Total bilirubin, mean (SD)	0.6 (0.3)	0.4 (0.2)	< 0.001
Albumin, g/dL, mean (SD)	3.0 (0.8)	3.4 (0.7)	0.01

¹Other gastro-intestinal symptoms include loss of taste or smell, constipation, dysphagia, reflux and vomiting.

²X-ray findings including ground glass opacities and bilateral infiltrate. All values are reported as n (%), mean (SD) or median (25^th, 75^th). P value: Chi-square test for categorical variables, two-sided t-test for parametric continuous variables and Wilcoxon rank-sum test for nonparametric continuous variables. IQR: Interquartile range; GI: Gastrointestinal.