Obeticholic acid attenuates human immunodeficiency virus/alcohol metabolism-induced pro-fibrotic activation in liver cells

doi:10.4254/wjh.v12.i11.965

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Nov 27, 2020 (publication date) through May 18, 2024

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Nov 27, 2020; 12(11): 965-975
Published online Nov 27, 2020. doi: 10.4254/wjh.v12.i11.965

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Figure 5 Anti-fibrotic effects of obeticholic acid on hepatic stellate cells activated by engulfment of apoptotic Huh7. 5-CYP cells. A: Col1A1 mRNA; B: Transforming growth factor-β mRNA. All data were obtained from 3 independent experiments and presented as mean ± SEM. Bars with different letters are significantly different at P ≤ 0.05. TGF: Transforming growth factor; HIV: Human immunodeficiency virus; OCA: Obeticholic acid.

Citation: New-Aaron M, Ganesan M, Dagur RS, Kharbanda KK, Poluektova LY, Osna NA. Obeticholic acid attenuates human immunodeficiency virus/alcohol metabolism-induced pro-fibrotic activation in liver cells. World J Hepatol 2020; 12(11): 965-975
URL: https://www.wjgnet.com/1948-5182/full/v12/i11/965.htm
DOI: https://dx.doi.org/10.4254/wjh.v12.i11.965