Neoadjuvant treatment strategies for intrahepatic cholangiocarcinoma

Table 1 Rationale for the use of neoadjuvant therapy in intrahepatic cholangiocarcinoma

	Rationale for the use of neoadjuvant therapy in ICC
1	Downstaging of locally advanced tumors
2	Improve margin-negative resection rate
3	Increase receipt of systemic therapy given challenges in delivering postoperative chemotherapy
4	Prioritize the early systemic treatment of potential micrometastatic disease
5	Enhance patient selection for major surgery
6	Facilitate an in vivo test of chemotherapy’s effectiveness

ICC: Intrahepatic cholangiocarcinoma.