Hepatic flow is an intraoperative predictor of early allograft dysfunction in whole-graft deceased donor liver transplantation: An observational cohort study

Table 3 Univariate and multivariate Cox regression models of mortality at 30 d

Variables	Univariate Cox regression			Multivariate Cox regression
	β	Relative risk (95%CI)	P value	β	Relative risk (95%CI)	P value
Donor
Age	1.03	(0.97-1.08)	0.28
Donor AST (IU/L)	1	(0.99-1.02)	0.84
Donor ALT (IU/L)	0.99	(0.97–1.02)	0.63
Donor GGT (IU/L)	1	(0.99–1.01)	0.93
Epinephrine dose (mg/kg/min)	0.03	(0.00–5.69)	0.93
Na levels in donor blood	0.93	(0.84–1.03)	0.19
DRI	4.49	(0.26–76.92)	0.3
ICU time (d)	1.04	(0.89–1.22)	0.62
Recipient
Age	1.04	(0.94-1,14)	0.43
MELD	0.88	(0.72–1.08)	0.22
MELD-Na	0.98	(0.87–1.11)	0.76
Creatinine (mg/dL)	1.08	(0.52–2.26)	0.83
AST basal (IU/L)	1	(1-1)	0.03
Bilirubin basal (mg/dL)	0.98	(0.88–1.09)	0.75
INR basal	1.03	(0.44–2.39)	0.95
Preservation
Cold ischaemia time (min)	1	(0.99–1.00)	0.31
Hot ischaemia time (min)	1	(0.98–1.04)	0.56
Total ischaemia time (min)	1	(0.99-1)	0.33
Intraoperative
Need red blood cells (units)	1.17	(0.91–1.50)	0.37
Need intraoperative platelets (units)	0.92	(0.70–1.20)	0.54
Need intraoperative plasma (units)	0.93	(0.60–1.43)	0.74
Need intraoperative cryoprecipitate (g)	1.1	(0.71–1.70)	0.68
Hepatic arterial flow (mL/min)	0.99	(0.97-1)	0.01
Portal venous flow (mL/min)	0.99	(0.99–1.00)	0.01
Total hepatic flow (mL/min)	0.99	(0.98–1.00)	0.04
HAF < 180 mL/min	5.9	(1.13–30.99)	0.04	5.33	(1.01–28.22)	0.04
PVF < 1200 mL/min	5.31	(1.02–27.70)	0.04
INR day 1 > 2,2	6.07	(1.11–33.22)	0.04
AST day 1 > 2000 UI/dL	10.82	(1.26–92.97)	0.03	9.856	(1.15–84.78)	0.04

DRI: Donor risk index; HAF: Hepatic artery flow; ICU: Intensive care unit; INR: International normalized ratio; MELD: Model of end liver disease; PVF: Portal vein flow; THF: Total hepatic flow.