Hepatic flow is an intraoperative predictor of early allograft dysfunction in whole-graft deceased donor liver transplantation: An observational cohort study

Table 2 Univariate and multivariate analysis for the development of early allograft dysfunction

Variables	Univariate analysis			Multivariate logistic regression
	EAD (n = 54)	Non-EAD (n = 141)	P value	β	Relative risk (95%CI)	P value
Donor
Age	62.30 ± 15.67	58.17 ± 18.10	0.21
Donor AST (IU/L)	50.77 ± 56.65	43.44 ± 43.88	0.71
Donor ALT (IU/L)	48.64 ± 53.36	38.97 ± 51.51	0.04
Donor GGT (IU/L)	70.67 ± 111.53	60.63 ± 116.96	0.59
Epinephrine dose (mg/kg/min)	0.27 ± 0.32	0.30 ± 0.36	0.78
Na levels in donor blood	147.13 ± 8.52	146.94 ± 8.47	0.99
DRI	1.61 ± 0.29	1.57 ± 0.32	0.46
ICU time (d)	4.13 ± 4.83	3.17 ± 3.75	0.64
Recipient
Age	52.11 ± 9.21	51.89 ± 10.21	0.88
MELD	15.11 ± 6.86	15.37 ± 6.83	0.73
MELD-Na	17.49 ± 7.57	17.71 ± 7.66	0.99
Creatinine (mg/dL)	0.91 ± 0.48	1.08 ± 1.09	0.26
GOT basal (IU/L)	426.88 ± 1168.84	164.58 ± 435.5	0.52
Bilirubin basal (mg/dL)	7.21 ± 8.74	6.23 ± 8.14	0.74
INR basal	1.61 ± 0.69	1.58 ± 1.06	0.53
Preservation
Cold ischaemia time (min)	525.74 ± 153.03	464.94 ± 142.52	0.01
Hot ischaemia time (min)	57.26 ± 21.08	54.57 ± 22.4	0.20
Total ischaemia time (min)	584.17 ± 154.18	520.53 ± 139.1	0.01
Intraoperative
Intraoperative red blood cells (units)	3.00 ± 2.54	3.08 ± 3.18	0.73
Intraoperative platelets (units)	2.00 ± 2.69	2.56 ± 3.76	0.83
Intraoperative plasma (units)	0.91 ± 1.72	0.75 ± 1.74	0.53
Intraoperative cryoprecipitate (g)	1.59 ± 1.57	1.44 ± 1.86	0.22
Hepatic arterial flow (mL/min)	227.74 ± 134.13	279.67 ± 152,8	0.01
Portal venous flow (mL/min)	1363.84 ± 602.06	1606.7 ± 491.5	0.01
Hepatic total flow (mL/min)	1591.81 ± 631.07	1883.2 ± 513.1	0.01
HAF < 180 mL/min				2.41	(1.18-4.89)	0.02
PVF < 1200 mL/min				2.89	(1.45-5.73)	0.01
TIT > 610 min				2.31	(1.15-4.65)	0.02

DRI: Donor risk index; HAF: Hepatic artery flow; ICU: Intensive care unit; INR: International normalized ratio; MELD: Model of end liver disease; PVF: Portal vein flow; THF: Total hepatic flow.