Proton pump inhibitors increase the severity of hepatic encephalopathy in cirrhotic patients

doi:10.4254/wjh.v11.i6.522

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Jun 27, 2019; 11(6): 522-530
Published online Jun 27, 2019. doi: 10.4254/wjh.v11.i6.522

Table 1 Grade of hepatic encephalopathy in proton pump inhibitor users versus nonusers

Grade of HE	PPI user	PPI nonuser
Grade of HE	n = 75	n = 28
Grade 1	15 (20.0)	11 (39.3)
Grade 2	32 (46.6)	13 (46.4)
Grade 3	18 (24.0)	4 (14.3)
Grade 4	10 (13.4)	0 (0)

n (%), Grade of hepatic encephalopathy (HE) is defined by the West Haven Criteria Severity Scale for HE: Grade I (mild confusion, disordered sleep), II (lethargy moderate confusion), III (marked confusion, incoherent speech), IV (coma). HE: Hepatic encephalopathy; PPI: Proton pump inhibitor.

Citation: Fasullo M, Rau P, Liu DQ, Holzwanger E, Mathew JP, Guilarte-Walker Y, Szabo G. Proton pump inhibitors increase the severity of hepatic encephalopathy in cirrhotic patients. World J Hepatol 2019; 11(6): 522-530
URL: https://www.wjgnet.com/1948-5182/full/v11/i6/522.htm
DOI: https://dx.doi.org/10.4254/wjh.v11.i6.522