Angiogenesis of hepatocellular carcinoma: An immunohistochemistry study

Table 3 Assessment of COX-2 and VEGF-A expression in HCC

Parameter		COX-2 intensity			P value	VEGF-A intensity			P value
	1+		2+	3+		1+	2+	3+
n (%)	14 (28)		18 (36)	18 (36)		12 (24)	28 (56)	10 (20)
Gender
Males	10		12	14	0.75	8	22	6	0.47
Females	4		6	4		4	6	4
Age groups (yr)
31-50	0		0	2	0.47	0	1	1	0.33
51-60	4		4	4		5	4	3
61-70	5		10	6		4	12	5
71-80	5		4	6		3	11	1
Tumor grade
G1+G2	13		7	12	0.006	6	19	7	0.50
G3+G4	1		11	6		6	9	3
Tumor stage
pT1	7		6	10	0.38	3	12	8	0.03
pT2	7		12	8		9	16	2
Associated lesions
With cirrhosis	8		3	7	0.05	5	9	4	0.81
Without cirrhosis	6		15	11		7	19	6
With Mallory bodies	7		5	2	0.05	4	7	3	0.85
Without Mallory bodies	7		13	16		8	21	7
With hepatitis	7		9	8	0.93	6	14	4	0.85
Without hepatitis	7		9	10		6	14	6

VEGF: Vascular endothelial growth factor; COX-2: Cyclooxygenase-2.