Hepatocellular carcinoma recurrence after liver transplantation: Risk factors, screening and clinical presentation

Table 2 RETREAT score to estimate the risk of tumor recurrence after liver transplantation in patients with tumors within the Milan criteria and proposed protocol for tumor recurrence screening[74]

Risk factor	Score
Alpha-fetoprotein level before LT
0–20 ng/mL	0
21–99 ng/mL	1
0–999 ng/mL	2
> 1000 ng/mL	3
Microvascular invasion	2
Sum of the diameter of the largest viable tumor and the number of viable nodules
0	0
1.1–4.9	1
5.0–9.9	2
≥ 10	3
RETREAT Score	Screening Protocol
0 points	Screening not needed
1-3 points	Screening every 6/6 mo for 2 yr
4 points	Screening every 6/6 mo for 5 yr
≥5 points	Screening every 3-4 mo for 2 yr Exams every 6 mo between the 2nd and 5th year

TR: Tumor recurrence; LT: Liver transplantation.