Comprehensive analysis of HFE gene in hereditary hemochromatosis and in diseases associated with acquired iron overload

Table 3 Linkage disequilibrium between HLA-B alleles and HFE coding region H63DC>G single nucleotide polymorphism alleles

	Observed frequency		Expected frequency		Standardized value of disequilibrium(D’)		Standardized value of correlation(r2)	QUI2value	P value of QUI2
HLA-B	HFE H63DC>G
	C	G	C	G	C	G
07	16	2	14.83	3.17	0.3683	-0.3683	0.0029	0.5728	0.4492
08	12	1	10.71	2.29	0.5626	-0.5626	0.0047	0.9396	0.3324
13	3	1	3.30	0.70	-0.0899	0.0899	0.0008	0.1547	0.6941
14	10	0	8.24	1.76	1.0000	-1.0000	0.0113	2.2471	0.1339
15	17	0	14.01	2.99	1.0000	-1.0000	0.0199	3.9669	0.0464
18	10	0	8.24	1.76	1.0000	-1.0000	0.0113	2.2471	0.1339
27	2	2	3.30	0.70	-0.3933	0.3933	0.0149	2.9586	0.0854
35	17	4	17.31	3.69	-0.0177	0.0177	0.0002	0.0345	0.8526
37	1	2	2.47	0.53	-0.5955	0.5955	0.0254	5.0617	0.0245
38	3	0	2.47	0.53	1.0000	-1.0000	0.0033	0.6500	0.4201
39	4	2	4.94	1.06	-0.1911	0.1911	0.0053	1.0582	0.3036
40	3	0	2.47	0.53	1.0000	-1.0000	0.0033	0.6500	0.4201
41	3	0	2.47	0.53	1.0000	-1.0000	0.0033	0.6500	0.4201
42	1	0	0.82	0.18	1.0000	-1.0000	0.0011	0.2145	0.6433
44	8	11	15.66	3.34	-0.4891	0.4891	0.11831	23.5443	< 0.00001
45	6	0	4.94	1.06	1.0000	-1.0000	0.0066	1.3203	0.2505
48	2	0	1.65	0.35	1.0000	-1.0000	0.0022	0.4312	0.5114
49	8	0	6.59	1.41	1.0000	-1.0000	0.0089	1.7788	0.1823
50	2	0	1.65	0.35	1.0000	-1.0000	0.0022	0.4312	0.5114
51	9	5	11.54	2.46	-0.2199	0.2199	0.0172	3.4137	0.0647
52	7	0	5.77	1.23	1.0000	-1.0000	0.0078	1.5484	0.2134
53	5	0	4.12	0.88	1.0000	-1.0000	0.0055	1.0946	0.2955
55	2	0	1.65	0.35	1.0000	-1.0000	0.0022	0.4312	0.5114
56	0	1	0.82	0.18	-1.0000	1.0000	0.0237	4.7094	0.0300
57	8	2	8.24	1.76	-0.0293	0.0293	0.0002	0.0423	0.8371
58		2	4.94	1.06	-0.1911	0.1911	0.0053	1.0582	0.3036
67	1	0	0.82	0.18	1.0000	-1.0000	0.0011	0.2145	0.6433

¹The higher value of correlation. Identification of single nucleotide polymorphisms and most frequent allele according to NCBI (http://www. ncbi.nlm.nih.gov) and Ensembl (http://www.ensembl.org): rs1799945 (H63DC>G). Shaded cells are showing significant LD values.