Serum biomarkers and risk of hepatocellular carcinoma recurrence after liver transplantation

Table 2 Main selection criteria for liver transplantation including des-gamma-carboxyprothrombin

Reference	Country	n	Cutoff values	Criteria	Validated in
Takada et al[61],2007	Japan	125	DCP: 400	Kyoto criteria: up to 10 tumors ≤ 5 cm and DCP ≤ 400	Fujiki et al[63], 2009; Kaido et al[64], 2013
Soejima et al[62], 2007	Japan	60	DCP: 300	Kyushu criteria: any number of tumors < 5 cm and DCP < 300	Shirabe et al[65], 2011
Todo et al[66], 2007	Japan	551	AFP:200, DCP: 100	A-P level: AFP ≤ 200 and DCP ≤ 100
Chaiteerakij et al[70], 2015	United States	127	AFP:250, DCP: 7.5
Yang et al[67], 2016	Korea	88 (training cohort); 198 (validation cohort)	AFP: 200; DCP: 200	A-P 200: AFP ≤ 200 or DCP ≤ 200
Kim et al[68], 2016	Korea	461	AFP: 150; DCP:100	--
Lee et al[69], 2016	Korea	566	AFP and DCP; continuous variables	MoRAL score: 11x√ DCP + 2x√AFP

AFP: Alpha-fetoprotein; DCP: Des-gamma-carboxyprothrombin; MoRAL: Model of recurrence after liver transplantation.