Serum biomarkers and risk of hepatocellular carcinoma recurrence after liver transplantation

Table 1 Main selection criteria for liver transplantation including alpha-fetoprotein

Reference	Country	n	AFP cutoff, ng/mL	Criteria	Validated in
Yang et al[34], 2007	Korea	63	20, 200 and 1000	Tumor number, tumor size and AFP level with different cutoffs
Zheng et al[35], 2008	China	195	400	Hangzhou criteria: (1) TTD ≤ 8 or (2) TTD > 8, well or moderately differentiated and AFP < 400
Toso et al[36], 2009	SRTR database	6487	400	TTV/AFP criteria for overall survival after LT: TTV ≤ 115cm3 and AFP ≤ 400	Validated for recurrence after LT: Grat et al[37], 2013; Toso et al[38],2015.
Duvoux et al[17], 2012	France	537 (training cohort); 435 (validation cohort)	100 and 1000	AFP model: tumor number, tumor size and AFP level with different cutoffs	Varona et al[39], 2015; Notarpaolo et al[20], 2017; Piñero et al[40], 2016; Rhu et al[41], 2018
Lai et al[45], 2012	Italy	158	400	AFP-TTD criteria: TTD < 8 cm and AFP < 400
Grąt et al[42], 2014	Poland	101	100	Warsaw criteria: (I) fulfillment of Milan criteria; or (II) Up-to-7 or UCSF criteria and AFP < 100	Piñero et al[43], 2016; Grat et al[44], 2017
Kim et al[46], 2014	Korea	180	1000	Samsung criteria: Up to 7 tumors ≤ 6 cm, and AFP ≤ 1000

AFP: Alpha-fetoprotein; LT: Liver transplantation; SRTR: Scientific Registry of Transplant Recipients; TTD: Total tumor diameter; TTV: Total tumor volume; UCSF: University of California San Francisco.