Glycogenic hepatopathy: A narrative review

Table 2 Summary of the major studies in English (pub med indexed) on Glycogenic hepatopathy in type 1 diabetes mellitus

Ref.	Study design	Age/sex	HbA1C	Keto acidosis	Hepatomegaly	Liver abnormality	Normalization of LFTs
Chatila et al[43], 1996	Retrospective Study	Mild Fibrosis (14%)	11patients (8-A and 3-P)
		41/F	NA	NA	No	20/45/1.4 x ULN/0.35	Few days to weeks
		21/F	NA	NA	No	282/404/0.4 x ULN/0.28	Few days to weeks
		58/F	NA	NA	Yes	35/56/3.2 x ULN/0.40	Few days to weeks
		70/F	NA	NA	Yes	76/NA/NA/1.28	Few days to weeks
		36/F	NA	NA	No	40/86/2.1 x ULN/0.28	Few days to weeks
		46/F	NA	NA	Yes	22/20/1.7 x ULN/N	Few days to weeks
		23/F	NA	NA	Yes	265/410/9.5 x ULN/0.40	Few days to weeks
		19/F	NA	NA	Yes	344/532/2.6 x ULN/0.8	Few days to weeks
		13/M	NA	NA	Yes	940/910/2 x ULN/0.30	Few days to weeks
		13/M	NA	NA	Yes	85/NA/0.3 x ULN/0.48	Few days to weeks
		15/M	NA	NA	Yes	NA/NA/1.9 x ULN/0.08	Few days to weeks
Torbenson et al[44], 2006	Retrospective Study	14 patients
		19/F	NA	Yes	Yes	97/83/80/NA	NA
		1/2M	13.5	Yes	Yes	49/47/182/NA	NA
		22/F	NA	No	Yes	48/77/62/NA	NA
		8/M	NA	No	Yes	Elevated/NA	NA
		15/F	NA	No	NA	Normal	NA
		22/M	16	Yes	Yes	1100/360/251/NA	NA
		25/M	10.8	NA	NA	1629/1128/298/NA	NA
		16/M	NA	Yes	NA	Elevated/NA	NA
		20/M	9.9	No	yes	N/120/147/NA	NA
		18/F	10.8	No	NA	N/57/N/NA	NA
		28/M	NA	No	NA	1099/1544/384/NA	NA
		34/M	10.1	No	Yes	N/NA/N/NA	NA
		16/M	NA	No	Yes	1413/1354/476/NA	NA
		23/F	NA	No	Yes	255/224/307/NA	NA
Fitzpatrick et al[45], 2014	Retrospective	31 patients	11(Mean)	Yes-all	76/76/NA/NA(M)	NA	14 (73%) Fibrosis
		16M/15F	12Mild and 2Bridging
		Median age 15	Fibrosis
Mukewar et al[46], 2017	Case control study	20 patients	11.4(Mean) 55%	88.90%	301/308/170/0.5(M)	8 mo	10% Mild fibrosis but no bridging fibrosis
		16F/4M
		24-A, 12-P

T1DM: Type 1 diabetes mellitus; HbA1C: Hemoglobin A1c; AST: Aspartate transferase; ALT: Alanine transferase; ALP: Alkaline phosphatase; T bili: Total bilirubin; M: Male; F: Female; NA: Not available; A: Adults; P: Pediatrics.