Glycogenic hepatopathy: A narrative review

Table 1 Summary of the major case reports in English (pub med indexed) on Glycogenic hepatopathy in type 1 diabetes mellitus

Ref.	Study design	Age/sex	HbA1C	Keto acidosis	Hepatomegaly	AST/ALT/ALP/T bili	Normalization of LFTs
Ruschhaupt et al[1], 1970	Case report	13/M	NA	Yes	Yes	9/14/115/128/NA	5 d
Berman et al[2], 1973	Case report	21/F	NA	Yes	Yes	UK	Expired (5 d)
Olsson et al[3], 1989	Case report	15/F	NA	Yes	Yes	535/417/570/NA	10 d
		20/F	NA	No	Yes	1117/1235/941/NA	18 mo
		24/F	NA	Yes	No	323/276/429/NA	NA
Munns et al[4], 2000	Case reports	13/M	14.1	No	Yes	132/135/170/NA	4 wk
		17/F	13.3	No	Yes	102/147/175/NA	2 wk
		16/F	12.2	No	Yes	567/316/196/NA	2 wk
Fridell et al[5], 2007	Case report	18/F	NA	Yes	Yes	Elevated/N	After pancreatic transplant
		21/M	NA	No	Yes	Elevated/N	After pancreatic transplant
Cuthbertson et al[6], 2007	Case report	19/F	12.2	Yes	Yes	NA/800/132/N	NA
Sayuk et al[7], 2007	Case report	19/F	8.1	Yes	Yes	98/49/147/0.5	NA
		37/M	16.0	Yes	Yes	226/399/326/0.9	NA
Bassett et al[8], 2008	Case report	10/F	10.1	No	No	143/147/137/N	NA
Abaci et al[9], 2008	Case report	16/M	11.1	No	Yes	66/58/431/0.8	3 mo
Hudacko et al[10], 2008	Case report	20/F	13.3	No	Yes	249/383/NA/NA	5 mo
Sweetser et al[11], 2010	Case report	27/M	15.0	No	Yes	6720/2549/529/1.7	3 mo
Van Den Brand[12], 2009	Case report	29/F	15.3	No	No	2500/1000/316/NA	NA
Saxena et al[13], 2010	Case report	33/F	13.7	No	No	428/404/205/N	12 mo
Bua et al[14], 2010	Case report	17/F	12.0	No	Yes	138/164/NA/NA	12 mo
Aljabri et al[15], 2011	Case report	13/F	13.0	No	Yes	NA/500/137/N	3 mo
Dantuluri et al[16], 2012	Case report	14/F	11.0	No	Yes	Elevated	Few days
Lin et al[17], 2012	Case report	10/ F	12.8	Yes	Yes	121/194/185/NA	6 mo
Messeri et al[18], 2012	Case report	31/F	10.3	No	Yes	225/258/375/0.54	2 mo
Murata et al[19], 2012	Case report	21/M	6.2	Yes	No	119/122/NA/NA	25 d
Cha et al[20], 2012	Case report	22/F	13.8	No	Yes	1028/365/346/0.5	8 wk
		26/F	12.9	Yes	Yes	914/307/189/0.5	4 wk
		20/F	13.6	No	No	1310/346/132/0.2	16 wk
Saadi T[21], 2012	Case report	18/M	11.0	No	Yes	144/92/123/1.4	3 mo
Saikusa et al[22], 2012	Case report	13/M	12.0	No	Yes	100/191/NA/NA	NA
Imtiaz et al[23], 2013	Case report	19/F	14.6	Yes	Yes	NA/199/139/NA	5 mo
Butts et al[24], 2014	Case report	13/F	8.8	Yes	Yes	NA/113/NA/NA	NA
Jeong et al[25], 2014	Case report	13/F	10.7	Yes	Yes	105/84/NA/NA	3 mo
Martin et al[26], 2014	Case report	13/M	10.4	Yes	Yes	3969/1196/NA/NA	16 d
Parmar et al[27], 2015	Case report	21/F	NA	Yes	Yes	4202/973/N/N	1 wk
Xu et al[28], 2015	Case report	22/M	14.6	No	Yes	331/223/223/0.3	NA
Garcia-Suarez et al[29], 2015	Case report	28/F	10.5	No	Yes	1600/534/N/N	NA
Atmaca et al[30], 2015	Case report	19/M	NA	Yes	Yes	603/570/921/NA	3 wk
Irani et al[31], 2015	Case report	19/M	12.0	Yes	Yes	505/345/145/N	NA
Brouwers et al[32], 2015	Case report	19/F	9.5	No	Yes	Elevated	NA
		19/F	13.3	No	Yes	Elevated	NA
		17/M	12.7	No	Yes	Elevated	NA
		20/F	14.7	No	Yes	Elevated	NA
Charndrasekaran et al[33], 2015	Case report	5/F	16.1	Yes	Yes	53/20/NA/0.7	NA
Silva et al[34], 2016	Case report	21/F	9.0	Yes	Yes	110/120/190/0.74	Few days
		20/F	10.1	Yes	Yes	270/423/179/1	Few days
		29/F	10.9	No	Yes	910/461/172/0.35	3 mo
		22/M	15.7	Yes	Yes	226/109/79/0.64	2 wk
Deemer et al[35], 2016	Case report	18/F	11.3	Yes	Yes	NA/36/120/N	NA
Saracho et al[36], 2016	Case report	14/M	12.8	Yes	Yes	Elevated	NA
Chandel et al[37], 2017	Case report	12/F	10.5	Yes	Yes	690/356/158/0.2	3 mo
Ikarashi et al[38], 2017	Case report	21/M	11.7	No	Yes	2723/956/NA/NA	1 mo
		24/F	11.0	Yes	Yes	658/216/NA/NA	Few days
		19/F	13.6	Yes	Yes	737/266/NA/NA	Few days
		29/F	16.5	Yes	Yes	469/243/NA/NA	6 mo
Maharaj et al[39], 2017	Case report	23/F	12.3	Yes	Yes	127/199/160/2.7	Few days
Al Sarkhy et al[40], 2017	Case report	6/M	11.6	Yes	Yes	367/205/221/N	Few days
Shah et al[41], 2017	Case report	31/F	NA	Yes	Yes	627/185/280/0.7	NA
Omer[42], 2017	Case report	14/M	11.0	Yes	Yes	Normal	NA

HbA1C: Hemoglobin A1c; AST: Aspartate transferase; ALT: Alanine transferase; ALP: Alkaline phosphatase; T bili: Total bilirubin; M: Male; F: Female; NA: Not available.