Autoimmune hepatitis: Appraisal of current treatment guidelines

doi:10.4254/wjh.v10.i12.911

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Dec 27, 2018 (publication date) through May 5, 2024

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Dec 27, 2018; 10(12): 911-923
Published online Dec 27, 2018. doi: 10.4254/wjh.v10.i12.911

Table 2 Simplified diagnostic criteria of the International Autoimmune Hepatitis Group

Parameter	Discriminator	Score
ANA or ASMA	≥ 1:40	+ 1¹
ANA or ASMA	≥ 1:80	+ 2¹
Anti-LKM	≥ 1:40	+ 2¹
Anti-SLA/LP	Any titer	+ 2¹
Total IgG	> ULN	+ 1
Total IgG	> 1.1 × ULN	+ 2
Liver histology	Compatible with AIH	+ 1
Liver histology	Typical of AIH	+ 2
Absence of viral hepatitis	No	0
Absence of viral hepatitis	Yes	+ 2

¹Addition of all points for autoantibodies must be done, maximum 2 points allowed. Definite autoimmune hepatitis (AIH) ≥ 7; Probably ≥ 6. Typical histology for AIH: Each of the following should be present, interface hepatitis, plasma cell infiltrates, emperiopolesis, and hepatic rosette formation. Compatible liver histology: Chronic hepatitis with lymphocytic infiltrations without typical features as above. AIH: Autoimmune hepatitis; ANA: Antinuclear antibody; ASMA: Anti-smooth muscle antibody; Anti-LKM: Anti-liver kidney microsomal antibody; Anti-SLA/LP: Anti-soluble liver antigen/liver pancreas antibody[18].

Citation: Lowe D, John S. Autoimmune hepatitis: Appraisal of current treatment guidelines. World J Hepatol 2018; 10(12): 911-923
URL: https://www.wjgnet.com/1948-5182/full/v10/i12/911.htm
DOI: https://dx.doi.org/10.4254/wjh.v10.i12.911