Bioengineered humanized livers as better three-dimensional drug testing model system

Figure 5 Functional assessment of humanized liver. A and B: Quantification of double stranded DNA (dsDNA) in (A) liver perfusate showing reduction in quantity at day 7 whereas (B) in humanized liver post-repopulation showed reciprocal relationship which was significantly high (^bP < 0.001) at day 7 as compared to day 1 and was almost similar to the fresh liver (FL); C-E: The rate of (C) albumin secretion (D) lactate dehydrogenase release and (E) urea synthesis in humanized livers at different time points showing improved response as compared to the conventional 2D-cultures.