Efficacy of direct-acting antiviral treatment for chronic hepatitis C: A single hospital experience

Table 4 NS5A RASs and clinical course in patients with failure of DAAs

Patient No.	Sex	Age in yr	LC1	HCC2	Initial DAA	NS5A RASs			Second DAA	Second result
						Before DAA	After DAA (invader)	After DAA (cycleave)
1	Female	73	No	No	DCV/ASV	NA	Y93H L31F Q54H A92V	Y93 mutant L31 mutant	LDV/SOF/RBV	SVR
2	Female	77	Yes	Yes	DCV/ASV	NA	Y93H L31M Q24Q/R	Y93 mutant L31 mutant	LDV/SOF/RBV	Relapse
3	Female	71	Yes	No	DCV/ASV	NA	NA	Y93 wild-type L31mutant	LDV/SOF/RBV	SVR
4	Female	78	Yes	No	DCV/ASV	NA	NA	Y93 mutant L31 mutant	LDV/SOF/RBV	SVR
5	Male	74	Yes	Yes	DCV/ASV	NA	Y93H L31V Q54y Q62D	Y93 mutant L31 mutant	LDV/SOF	SVR
6	Female	83	Yes	Yes	DCV/ASV	Y93Y/H L31L	Y93H L31M L31V	Y93 mutant L31 wild-type	No	NA
7	Male	71	Yes	No	DCV/ASV	Y93Y L31L	NA	Y93 wild-type L31 mutant	DCV-TRIO	Undergoing
8	Female	66	No	No	LDV/SOF	Y93Y L31L	NA	Failure	Waiting	NA
9	Male	78	Yes	Yes	LDV/SOF	NA	NA	Failure	Waiting	NA

¹Diagnosed as cirrhosis;

²A history of curative treatment for hepatocellular carcinoma. DAA: Direct-acting antivirals; DCV/ASV: Daclatasvir/asunaprevir; DCV-TRIO: Daclatasvir/asunaprevir/beclabuvir; LDV/SOF: Ledipasvir/sofosbuvir; NA: Data not available; RAS: Resistance-associated substitution; RBV: Ribavirin; SVR: Sustained virologic response. Failure: Could not be detected.