Current state and clinical outcome in Turkish patients with hepatocellular carcinoma

Table 3 Univariate logistic regression analyses of possible predictors of extrahepatic metastasis (n = 545)

	Univariate
	OR	95%CI	P value
Total tumor diameter
≥ 5 cm	3.19	1.18-8.59	0.022
Tumor type
Solitary HCC	Reference	-	-
Multinodular HCC	1.17	0.52-2.66	0.71
Diffuse-infiltrative HCC	1.06	0.13-8.43	0.96
Vascular invasion	1.86	0.53-6.51	0.33
HBV infection	1.76	0.73-4.26	0.21
Number of nodules	1.21	0.92-1.59	0.18
Stage of liver disease
Normal or precirrhotic liver	Reference	-	-
Child-Pugh A	2.29	0.51-10.2	0.28
Child-Pugh B	1.22	0.23-6.47	0.81
Child-Pugh C	1.14	0.19-7.01	0.89
AFP level
> 100 ng/mL	1.30	0.59-2.85	0.52
> 200 ng/mL	1.59	0.72-3.50	0.25
> 400 ng/mL	1.48	0.64-3.39	0.36
> 1000 ng/mL	1.91	0.81-4.52	0.14

HCC: Hepatocellular carcinoma; HBV: Hepatitis B virus; AFP: Alfa-fetoprotein.