Observational Study
Copyright ©The Author(s) 2018.
World J Hepatol. Jan 27, 2018; 10(1): 124-133
Published online Jan 27, 2018. doi: 10.4254/wjh.v10.i1.124
Table 1 Baseline characteristics of patients from the polymorphism group and the wild-type group
Polymorphism group (n = 28)Wild-type group (n = 230)P value
Age (yr)65.93 ± 12.164.90 ± 12.70.74
Gender (male/female)17 (60.7)/ 11 (39.3)128 (55.7)/ 102 (44.3)0.69
Cause of cirrhosis (%)0.07
Alcohol14 (50)125 (54.3)
Hepatitis C virus11 (39.3)82 (35.7)
Hepatitis B virus0 (0)8 (3.5)
Alcohol + HCV/HVB6 (21.4)18 (7.8)
Others3 (10.7)22 (9.6)
Active alcoholism (%)9/20 (45)80/143 (55.9)0.84
Diabetes mellitus (%)9 (32.1)75 (32.6)1.00
Child-Pugh score8.25 ± 18.31 ± 1.60.95
MELD score15.29 ± 4.815.35 ± 6.20.69
Previous decompensations (%)20 (71.4)160 (69.6)1.00
Previous ascites (%)19 (67.9)151 (65.7)1.00
Previous encephalopathy (%)13 (46.4)51 (22.2)0.009
Previous variceal bleeding (%)7 (25)54 (23.5)0.82
Previous spontaneous bacterial peritonitis (%)3 (10.7)16 (7)0.44
Hepatocellular carcinoma (%)4 (14.3)26 (11.3)0.55
Norfloxacin prophylaxis (%)4 (14.3)18 (7.8)0.28
Beta-blockers (%)10 (35.7)74 (32.2)0.68
Diuretics (%)15 (53.6)135 (58.7)0.69
Serum sodium (mmol/L)135.14 ± 6.3135.14 ± 9.80.78
Serum urea (mmol/L)9.6 ± 4.19.6 ± 9.10.18
Serum creatinine (μmol/L)117.29 ± 59.6100.6 ± 59.90.01
Serum bilirubin (μmol/L)54.7 ± 59.743 ± 34.10.64
Serum albumin (g/L)26.6 ± 5.527.9 ± 5.50.43
Prothrombin time ratio1.51 ± 0.241.57 ± 0.670.65
Ascitic fluid total protein (g/L)13.9 ± 6.615.6 ± 10.70.30
First decompensation1
Ascites (%)19 (67.8)165 (71.7)0.66
Encephalopathy (%)3 (10.7)6 (2.6)0.06
Variceal bleeding (%)4 (14.3)44 (19.1)0.79
Infection (%)2 (7.1)12 (5.2)0.65
Cause of current admission2
Ascites (%)8 (28.6)101 (43.9)0.15
Encephalopathy (%)5 (17.9)22 (9.6)0.18
Variceal bleeding (%)3 (10.7)31 (13.5)1.00
Spontaneous bacterial peritonitis (%)6 (21.4)33 (14.3)0.39
Other infection (%)3 (10.7)13 (5.7)0.39
Other (%)3 (10.7)30 (13)1.00