Proton nuclear magnetic resonance-based metabonomic models for non-invasive diagnosis of liver fibrosis in chronic hepatitis C: Optimizing the classification of intermediate fibrosis

Table 1 Main demographic and laboratory characteristics of 69 chronic hepatitis C patients from Pernambuco/Brazil

Characteristics	Total (n = 69)
Gender (n, %)
Male	28	40.60%
Female	41	59.40%
Age (yr)1	57.5	± 11.9
BMI (kg/m2)1	27.7	± 4.7
AST (U/L)2	51.5	(33.7-88)
ALT (U/L)2	54	(32.6-106)
AST/ALT1	1.03	± 0.44
GGT (U/L)2	81.8	(46.5-155)
Platelets (109/mm3)1	191	± 78
Albumin (g/dL)1	4.08	± 0.56
Total bilirubin (mg/dL)2	0.7	(0.50-1.09)
Alkaline phosphatase (U/L)1	94.6	± 49.2
INR1	1.09	± 0.14
APRI2	0.8	(0.44-2.18)
FIB-42	2.18	(1.29-4.72)
Liver fragment length (cm)2	1.5	(1.30-1.80)
Number of portal tracts2	15	(12.0-20.0)
Stage of fibrosis (n, %)
F0	2	2.90%
F1	25	36.20%
F2	14	20.30%
F3	10	14.50%
F4	18	26.10%

¹Mean ± standard deviation;

²Median (P₂₅-P₇₅). ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; BMI: Body mass index; GGT: Gamma glutamyl transferase; INR: International normalized ratio; APRI: Aspartate aminotransferase to platelet ratio index; FIB-4: Fibrosis index based on four factors.