Aggressive liver resection including major-vessel resection for colorectal liver metastases

Table 6 Univariate analysis for prognostic factors of the initial resection

			Survival (%)
Variables		n	3 years	5 years	P value
Patient-related
Age (yr)	≤ 64	158	66.9	53.1	0.83
	≥ 65	154	64.9	52.3
Gender	Male	195	68.2	53.0	0.77
	Female	117	62.4	51.9
Primary-related
Site	Colon	180	67.7	53.7	0.87
	Rectum	132	63.5	50.9
Histology	Moderate	192	67.1	52.1	0.41
	Others	120	64.1	53.5
Dukes stage	A/B	104	72.2	59.9	0.11
	C	208	62.7	48.8
Liver-related
Timing	Synchronous	156	63.7	48.5	0.17
	Metachronous	156	68.1	56.5
Distribution	Unilobar	181	72.2	59.0	< 0.01
	Bilobar	131	57.2	43.6
Number	≤ 2	188	72.6	61.2	< 0.01
	≥ 3	124	55.6	39.1
Maximum tumor size (mm)	≤ 30	169	75.0	61.7	< 0.01
	> 30	143	55.3	41.5
Prehepatectomy CEA (ng/mL)
	< 10	158	72.6	60.8	0.01
	≥ 10	145	60.1	44.5
Extrahepatic metastases	Present	44	40.9	26.7	< 0.01
	Absent	268	70.6	57.3
Treatment-related
Extent of hepatectomy	Major	113	57.9	39.8	< 0.01
	Minor	199	70.6	59.8
Tumor-free margin	Not exposed	256	70.5	58.7	< 0.01
	Exposed	56	46.6	27.9
PVE	Performed	49	51.0	37.4	< 0.01
	Not performed	263	68.8	55.2
Staged procedure	Performed	21	33.2	22.1	< 0.01
	Not performed	291	68.5	55.0
Hepatectomy with ablation	Performed	27	60.5	34.1	0.08
	Not performed	285	66.5	54.2
Prehepatectomy chemotherapy
	Performed	68	56.0	35.1	0.01
	Not performed	244	68.4	56.0
Adjuvant chemotherapy	Performed	257	67.0	54.6	0.02
	Not performed	55	63.1	42.0
Combined resection	Performed	16	55.4	24.6	0.02
	Not performed	296	66.5	54.0
Major vessel invasion	Positive	7	66.0	52.9	0.10
	Negative	305	66.0	52.9

Moderate, moderately differentiated adenocarcinoma; CEA: Carcinoembryonic antigen; PVE: Portal vein embolization.