Aggressive liver resection including major-vessel resection for colorectal liver metastases

Table 5 Outcomes of patients undergoing major vessel resection/reconstruction

		Initial resection			Second resection
Variables		Conventional (n = 296)	Combined (n = 16)	P value	Conventional (n = 37)	Combined (n = 7)	P value
Patient-related
Age, years		64	66	0.6	63	61	0.91
		(30-85)	(54-72)		(32-83)	(47-80)
Gender	Male	186 (63%)	9 (56%)	0.6	19 (51%)	5 (71%)	0.43
	Female	110 (37%)	7 (44%)		18 (49%)	2 (29%)
Primary-related
Site	Colon	169 (57%)	11 (69%)	0.61	27 (73%)	6 (86%)	0.66
	Rectum	127 (43%)	5 (31%)		10 (27%)	1 (14%)
Dukes stage	A or B	103 (35%)	3 (19%)	0.33	13 (35%)	1 (14%)	0.53
	C	193 (65%)	13 (81%)		24 (65%)	6 (86%)
Histology	Well	99 (33%)	7 (44%)	0.62	11 (30%)	2 (29%)	> 0.99
	Moderate	184 (62%)	8 (50%)		26 (70%)	5 (71%)
	Others	13 (4%)	1 (6%)		-	-
Liver-related
Timing	Synchronous	146 (49%)	10 (63%)	0.44
	Metachronous	150 (51%)	6 (38%)
Distribution	Unilobar	175 (59%)	6 (38%)	0.12	27 (73%)	5 (71%)	> 0.99
	Bilobar	121 (41%)	10 (63%)		10 (27%)	2 (29%)
Number		2	3.5	0.11	1	1	0.57
		(1-38)	(1-27)		(1-7)	(1-4)
Maximum tumor size (mm)		28	50	0.02	29	40	0.05
		(5-185)	(15-110)		(10-80)	(29-50)
Extrahepatic disease	Present	40 (14%)	4 (25%)	0.26	8 (22%)	1 (14%)	> 0.99
Prehepatectomy CEA (ng/mL)		8.3	43.9	< 0.01	8.6	21.5	0.45
		(1-10 536)	(2-4498)		(3-360)	(2-559)

Well, well differentiated adenocarcinoma; Moderate, moderately differentiated adenocarcinoma; CEA: Carcinoembryonic antigen.