Hepatic reactive lymphoid hyperplasia in a patient with primary biliary cirrhosis

Figure 1 Histopathological findings of the liver biopsy. Periportal lymphocytic infiltration with bile duct damage (arrows: damaged bile duct; hematoxylin and eosin stain, × 400).

Figure 2 Endoscopic picture of the stomach. The depressed lesion with spontaneous hemorrhage and irregular margins.

Figure 3 Contrast-enhanced abdominal computed tomography. A well-circumscribed nodule showing early arterial enhancement in S8 (arrow).

Figure 4 Histopathological findings of the gastric carcinoma and liver nodule. A: Signet ring cell carcinoma of the stomach invading into the deep submucosa (hematoxylin and eosin stain, × 40); B: A relatively well-circumscribed nodular proliferation of lymphocytes with lymphoid follicles in the liver (right: liver parenchyma, hematoxylin and eosin stain, × 40); C: Mantle zone and germinal center are sharply demarcated and a mixture of small and large lymphocytes and scattered tingible body macrophages is observed in the germinal center (hematoxylin and eosin stain, × 40).

Figure 5 Immunohistochemical findings of the liver nodule. CD3-positive T lymphocytes (left) and CD20-positive B lymphocytes (right) are regularly distributed (× 40).