Liver chemistries in severe or non-severe cases of COVID-19: A systematic review and meta-analysis

Figure 1 Study selection flow diagram. If all the liver chemistry indexes were not reported, these were regarded as “not available” and excluded from the meta-analysis. However, this study still enrolled studies that reported individual liver chemistry indexes if the severity of coronavirus disease 2019 was reported in relation with the index.

Figure 2 Forest plot of the association between serum alanine aminotransferase/aspartate aminotransferase level and disease severity. A: Pooled levels of alanine aminotransferase; B: Pooled levels of aspartate aminotransferase in the patients with coronavirus disease 2019. ALT: Alanine aminotransferase; AST: Aspartate aminotransferase.

Figure 3 Forest plot for the comparison of alanine aminotransferase and aspartate aminotransferase levels in the patients with coronavirus disease 2019 stratified by disease severity. A: Forest plot for the comparison of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in the non-severe cases of coronavirus disease 2019 (COVID-19); B: Forest plot for the comparison of ALT and AST levels in the severe cases of COVID-19. ALT: Alanine aminotransferase; AST: Aspartate aminotransferase.

Figure 4 Forest plot for the association of the cholestasis-related indexes and disease severity. A: Pooled levels of alkaline phosphatase; B: Pooled levels of γ-Glutamyltransferase; C: Pooled levels of total bilirubin; D: Pooled levels of direct bilirubin in the patients with coronavirus disease 2019. ALP: Alkaline phosphatase; GGT: γ-Glutamyltransferase; TBIL: Total bilirubin; DBIL: Direct bilirubin.

Figure 5 Forest plot for the association of the synthetic function-related indexes and disease severity. A: Pooled albumin levels; B: Globulin levels; C: Prothrombin times; D: International standardized ratios in the patients with coronavirus disease 2019. ALB: Albumin; GLB: Globulin; PT: Prothrombin time; INR: International standardized ratio.