Endometrial mesenchymal stem cells as a cell based therapy for pelvic organ prolapse

Figure 2 Schematic of changes in the human endometrium during the menstrual cycle, illustrating the growth, differentiation and shedding of the functionalis layer. The functionalis layer regenerates 4-10 mm during the proliferative phase (10 d) as cells proliferate in response to rising circulating estrogen levels. During the secretory phase, progesterone induces differentiation of the epithelium and stroma to generate an endometrium receptive to implantation of an embryo. This entire process occurs over 400 times during a woman’s reproductive life indicating the regenerative potential of human endometrium (reproduced from ref.[63] with permission).