Migration of bone marrow progenitor cells in the adult brain of rats and rabbits

Figure 6 Migration of bone marrow derived cells to the rabbit hippocampus. Sixteen months after injection of SV (RevM10.AU1) into the rabbit bone marrow (BM), transgene-positive cells were seen in the dentate gyrus. Numerous AU1-positive cells colocalized with NeuN, a marker of postmitotic neurons (not shown). A: Nestin+/AU1+ cells were seen mainly at the border SGZ/GCL, and more rarely in the GCL (arrows); B: DCX+ positive cells expressing AU1 were detected at the border SGZ/GCL and more rarely in the GCL (arrows). SGZ: Subgranular zone; GCL: Granular cell layer; DCX: Doublecortin.