Mucosal-associated invariant T cells from induced pluripotent stem cells: A novel approach for modeling human diseases

Table 3 Mucosal-associated invariant T cells in the diseases

Category	Mouse strains	Disease model	Phenotype	Ref.
Bacterial infection	MR1-/- Vα19 iTCR Tg Vβ6 Vβ8 Tg	Escherichia coliMicobacterium abcessus	Increase in the bacterial burden Repression of the bacterial burden	[16]
	MR1-/-	Klebsiella pneumoniae	Increased susceptibility to K. pneumoniae infection	[36]
	MR1-/-	Mycobacterium bovis BCG	Enhanced bacterial growth at the early stage of infection	[35]
		Francisella tularensis	Delayed adaptive immune reaction	[34]
Autoimmune diseases	Vα19 iTCR Tg	Experimental autoimmune encephalomyelitis (model of MS)	Suppressed disease induction and progression	[78]
	MR1-/-	Collagen-induced arthritis (model of rheumatoid arthritis)	Improved CIA score	[86]
	Adoptive transfer Jα33+ MAIT cells into BALB/c	TNBS induced colitis	Improved disease index	[105]
	B10.RIII	Spondyloarthropathy by IL-23	Enthesitis induced by IL-22 produced from IL-23R+RORγt+CD4-CD8- T cells (MAIT cells?) in the entheses	[91]
Others	Vα19 iTCR Tg NOD	Non-obese diabetes	Delayed disease onset	[106]
	Vα19 iTCR Tg	Delayed-type hypersensitivity to sheep erythrocytes (type IV allergy)	Suppression of the disease	[106]

MAIT: Mucosal-associated invariant T; IL: Interleukin; CIA: Collagen-induced arthritis; iTCR: Invariant T cell receptor.