Systematic Reviews
Copyright ©The Author(s) 2015.
World J Stem Cells. Jul 26, 2015; 7(6): 976-991
Published online Jul 26, 2015. doi: 10.4252/wjsc.v7.i6.976
Table 2 Histomorphometric results of the human studies included in the review
Ref.PatientsStudy designHistomorphometry (% of newly formed bone)
McAllister et al[74]55 MSA: MSCs + AL33.0 ± NR (16 wk)
Gonshor et al[75]1818 MSA: MSCs + AL32.5 ± 6.8 (12 wk)
8 MSA: AL18.3 ± 10.6 (12 wk)
Duttenhoefer et al[77]1112 MSA: BMAC + BBMNR
6 MSA: Ficoll + BBM
Rickert et al[78]1212 MSA: BMSCs + BBMNR
12 MSA: AB + BBM
Kühl et al[79]1313 MSA: BMA + BBMNR
13 MSA: BMAC + BBM
Wildburger et al[80]77 MSA: BMSCs + BBM7.4 ± 4.1 (12 wk)
13.5 ± 5.4 (24 wk)
7 MSA: BBM11.8 ± 6.2 (12 wk)
13.9 ± 8.5 (24 wk)
Sauerbier et al[81]2634 MSA: BMAC + BBM12.6 ± 1.7 (12 wk)
11 MSA: AB + BBM14.3 ± 1.8 (12 wk)
Rickert et al[82]1212 MSA: BMSCs + BBM17.7 ± 7.3 (14 wk)
12 MSA: AB + BBM12.0 ± 6.6 (14 wk)
Schmelzeisen et al[83]12 MSA: BMAC + BBM26.9 ± NR (12 wk)
Fuerst et al[84]1222 MSA: BMSCs + BBM17.9 ± 4.6 (24 wk)
Beaumont et al[85]36 MSA: PDSCs + BBMNR
Shayesteh et al[86]66 MSA: BMSCs + HA/β-TCP41.3 ± NR (24 wk)
Smiler et al[87]42 MSA: BMSCs + β-TCP40.0 ± NR (16 wk)
1 MSA: BMSCs + BBM13.0 ± NR (16 wk)
1 MSA: BMSCs + HA31.0 ± NR (16 wk)
Trautvetter et al[88]1010 MSA: PDSCs + PLGANR
Mangano et al[89]11 MSA: PDSCs + PLGA28.8 ± NR
Voss et al[91]3550 MSA: PDSCs + PLGANR
63 MSA: AB
Mangano et al[90]55 MSA: PDSCs + PLGA37.3 ± 19.5 (24 wk)
5 MSA: HA54.6 ± 21.1 (24 wk)
Zizelmann et al[92]2014 MSA: PDSCs + PLGANR
17 MSA: AB
Schimming et al[93]2727 MSA: PDSCs + PLGANR
Yamada et al[94]2323 MSA: BMSCs + PRPNR
Ueda et al[95]66 MSA: BMSCs + PRPNR