Contemporary perspective on endogenous myocardial regeneration

Figure 2 Hypothesis of embryonic recall. In embryos, the first heart beat is sensed by mechanotransduction of the endocardium, leading to a burst of developmental signals thriving cardiac morphogenesis. In analogy, elevated pressures in cardiac veins act via stretch and shear stress on perivascular cells, thus reiterating the same mechanotransductory signals in the adult failing heart. Pressure elevation in cardiac veins have to be pressure controlled not to increase arterial resistance to nutritive flow (PICSO).