Systems biology approach to developing S2RM-based “systems therapeutics” and naturally induced pluripotent stem cells

Figure 2 Regulation of the cancer/pluripotent phenotype by stem cells and extracellular matrix. The cancer/pluripotent cell phenotype can be regulated by the extracellular matrix (ECM) and stem cells, where cancer cells can be removed from a dysregulated ECM and placed into a normal ECM and the cancer/pluripotent phenotype will revert to a normal, somatic cell phenotype. Likewise, if a dysregulated ECM is reconstructed into a normal state, the cancer/pluripotent phenotype will revert to the normal somatic cell phenotype. Further regulation of the cancer/pluripotent phenotype can be regulated by a number of factors, including microRNA contained within exosomes that were released from mesenchymal stem cells serving to change the state of the cancer cell into one of quiescence. MBSC: BM-stroma cell.