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Copyright ©2014 Baishideng Publishing Group Inc.
World J Stem Cells. Jul 26, 2014; 6(3): 355-366
Published online Jul 26, 2014. doi: 10.4252/wjsc.v6.i3.355
Table 3 Summary of clinical trials: Effect of heart failure on endothelial progenitor cells
Ref.SubjectsEPCs (number/function)Findings
Valgimigli et al[28]45 healthy controls 91 CHFCD34+, CD34+/CD133+/KDR+ (flow cytometry)CD34+ and CD34+/CD133+/KDR+ are significantly elevated in CHF patients compared to controls EPC number is negatively correlated with NYHA functional class
Nonaka-Sarukawa et al[29]22 healthy controls 16 mild CHF 10 severe CHFCD34+ (flow cytometry)CD34+ is significantly higher in mild CHF compared to severe CHF
Michowitz et al[30]107 CHFCFUCFU is the independent predictor for CHF CFU is also negatively correlated with NYHA functional class