Dendritic cells derived from pluripotent stem cells: Potential of large scale production

doi:10.4252/wjsc.v6.i1.1

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Jan 26, 2014; 6(1): 1-10
Published online Jan 26, 2014. doi: 10.4252/wjsc.v6.i1.1

Table 1 Bioreactor systems for hematopoietic differentiation from pluripotent stem cells

Bioreactor type	PSC line	Performance	Ref.
Spinner flask	hESC lines: H9 and H1	15-fold expansion in cell number compared to 4-fold in static culture; 5%-6% CD34⁺ CD31⁺ cells	Cameron et al[27]
RWV	Mouse ESC line: R1	Hematopoietic differentiation in RWV generated more Sca-1⁺ cells; while spinner flasks generated more c-kit⁺ progenitors	Fridley et al[25]
Microcarrier-based spinner flask	hESC lines: WA01 (H1), WA09 (H9), HuES3, MA09; hiPSC line: IMR90-1	DE-53 microcarriers were used. EBs were formed 10 times more efficiently compared to 2-D culture; CFUs were similar to static culture	Lu et al[67]
Perfusion bioreactor	Mouse ESC line: D3 Mouse ESC line: CCE	Perfusion promoted hematopoietic differentiation; Perfusion in 3-D fibrous scaffolds supported 2-3 fold higher cell density compared to static culture; comparable CFU percentage	Wolfe et al[77]; Li et al[24]

hESC: Human embryonic stem cell; ESC: Embryonic stem cell; EBs: Embryoid bodies; hiPSC: Human induced pluripotent stem cell; RWV: Rotary wall vessel; CFU: Colony-forming units.

Citation: Li Y, Liu M, Yang ST. Dendritic cells derived from pluripotent stem cells: Potential of large scale production. World J Stem Cells 2014; 6(1): 1-10
URL: https://www.wjgnet.com/1948-0210/full/v6/i1/1.htm
DOI: https://dx.doi.org/10.4252/wjsc.v6.i1.1