In utero transplantation: Disparate ramifications

Table 2 Groups of 6 sheep were assessed for tolerance to allogeneic hematopoietic stem cells (HSC) and then re-transplanted after birth with same donor HSC

Allogeneic sheep HSC render recipient sheep1 tolerant following in utero transplantation
Stimulator	Responder	Stimulation index2
Donor	Donor	0
Recipient	Recipient	0
Donor	Recipient	0-8
Recipient	Donor	58 ± 11
Pooled	Donor	69 ± 12
Pooled	Recipient	78 ± 12
Postnatal infusion of allogeneic same donor HSC augments engraftment in tolerant sheep3
% donor cells at birth	n	% increase4
6-10	4	86 ± 29
11-15	5	63 ± 22
> 15	4	21 ± 11

¹Representative sample of 6 chimeric lambs;

²Variation of mixed lymphocyte reaction (MLR) previously reported[32];

³Tolerance determined via MLR[32];

⁴Assessed 6 mo after postnatal stem cell infusion (3 × 10⁸ cells/kg) in thirteen chimeric lambs rendered tolerant. HSC: Hematopoietic stem cell.