Impact of the antiproliferative agent ciclopirox olamine treatment on stem cells proteome

Table 9 Proteins which are downregulated upon ciclopirox olamine treatment compared to retinoic acid treated stem cells

	RA/CPX
	ESC	maGSC
Actb1	2.17	1.10
Aldh2	2.61	2.17
Aldh2	2.43	1.21
Aprt1	2.20	1.42
Atp5b	1.15	2.17
Capzb	2.79	2.07
Cct2*1	13.70	2.77
Eno11	2.48	2.02
Eno11	2.71	1.51
Fscn1	2.20	2.14
Gnb2l1	1.81	2.24
Hist1h2bb	7.53	1.62
Hist2h2ac	3.89	211.81
Hnrnpk	2.37	1.58
Hsp90aa1*1	2.69	6.36
Hsp90aa1	6.36	4.33
Hspa4*1	12.98	3.72
Hspa4	1.35	3.42
Krt7	> 100	1.14
Krt18*1	4.04	1.76
Ncl	1.80	3.48
Nme11	2.63	1.57
Nme2*1	5.72	11.15
Pdia6	1.74	6.33
Psmc21	2.87	1.20
Psmc4*1	3.06	2.26
Rps12*1	2	2.05
Tardbp	1.11	3.85
Uchl11	2.02	1.10
Vcp1	8.94	2.57

¹The proteins are referred to in the text and following tables;

²The protein was not identified in embryonic stem cells. Proteins, which are assigned an asterisk, were downregulated upon ciclopirox olamine (CPX) treatment compared to control and concurrently upregulated upon retinoic acid (RA) treatment compared to control. ESC: Embryonic stem cell; maGSC: Multipotent adult germline stem cell.