Impact of the antiproliferative agent ciclopirox olamine treatment on stem cells proteome

Table 7 Gene Ontology functional annotation of proteins which were regulated in this experiment according to their involvement in different molecular function

Molecular function	Proteins	CPX > RA	CPX < RA	CPX > c	CPX < c	RA > c	RA < c
Nucleotide binding	41	Hsp90ab1	Atp5b	Tubb2a	Cct2	Cct2	Ldhb
		Fkbp4	Cct2	Etfa	Tardbp	Hspa4	Fkbp4
		Tubb5	Tardbp	Hspa9	Hspa4	Myh9	Tubb5
		Hspa5	Hspa4	Actb	Tuba1c	Nme2	Hnrnpc
		Tubb1b	Actb	Myh9	Hspa8	Vcp	Hspa5
		Gapdh	Hsp90aa1	Vdac1	Hnrnpab	Psmc4	Tuba1c
		Etfa	Ncl	Atp5a1	Eef1a1	Nme1	Hspa8
		Hspa9	Aprt	Hspd1	Tcp1		Actb
		Actb	Nme2		Hsp90aa1		Hsp90aa1
		Hsp90aa1	Vcp		Ncl		Ncl
		Sfrs1	Psmc4		Aprt		Sfrs3
		Vdac1	Nme1		Ube2n		Aprt
		Pkm2	Psmc2		Nme2		Vdac1
		Atp5a1			Cct5		Pkm2
		Ruvbl1			Nme1		Pebp1
		Hspd1			Pkm2		Atp5a1
					Atp5a1		Ruvbl1
					Ruvbl1		Hspd1
					Hspd1
GTP binding	8	Fkbp4	Nme1	Tubb2a	Eef1a1	Nme1	Fkbp4
		Tubb5			Nme1		Tubb5
		Tuba1b			Tuba1c		Tuba1c
ATPase activity	8	Atp5a1	Vcp	Atp5a1	Atp5a1	Vcp	Atp5a1
			Psmc4	Myh9	Hspa8	Psmc4	Atp5h
			Atp5b			Myh9	Hspa8
			Psmc2
Enzyme binding	8	Actb	Actb	Actb	Gnb2l1	Vim	Actb
		Npm1	Gnb2l1	Hspd1			Pebp1
		Hspd1		Hspa9			Hspd1
		Cotl1					Cotl1
		Hspa9
Cofactor binding	5	Gapdh		Etfa	Shmt1		Ldhb
		Etfa					Shmt1
Peptidase activity	6	Ctsd	Uchl1	Ctsd	Psmb4		Psmb4
		Eno1	Eno1		Acy1		Uqcrc1
					Uchl1		Acy1
					Eno1		Eno1
Metal ion binding	13	Trim28	Atp5b		Acy1	Pdia6	Acy1
		Sfrs1	Pdia6		Nme2	Nme2	Uqcrc1
		Pkm2	Nme2		Nme1	Nme1	Trim28 Pkm2
		Glo1	Nme1		Pkm2		Glo1
		Eno1	Eno1		Impdh2		Impdh2
					Eno1		Eno1

Ciclopirox olamine (CPX) > Retinoic acid (RA): Proteins which were more than 2-fold higher expressed in CPX-treated cells compared to RA-treated cells; CPX < RA: Proteins which were more than 2-fold higher expressed in RA-treated cells compared to CPX-treated cells; CPX > c: Proteins which were more than 2-fold higher expressed in CPX-treated cells compared to control; CPX < c: Proteins which were more than 2-fold higher expressed in control compared to CPX-treated cells; RA > c: Proteins which were more than 2-fold higher expressed in RA-treated cells compared to control; RA < c: Proteins which were more than 2-fold higher expressed in control compared to RA-treated cells.