Impact of the antiproliferative agent ciclopirox olamine treatment on stem cells proteome

Table 2 Gene Ontology functional annotation of proteins which were regulated in this experiment according to their involvement in different biological processes

Biological process	Proteins	CPX > RA	CPX < RA	CPX > c	CPX < c	RA > c	RA < c
Monosaccharide metabolic/catabolic processes	5	Pgls	Eno1		Eno1		Eno1
		Gapdh			Pkm2		Ldhb
		Eno1					Pkm2
		Pkm2
Nucleobase, nucleoside, nucleotide, and nucleic acid biosynthetic processes	7	Atp5a1	Aprt	Atp5a1	Aprt	Nme2	Aprt
			Nme2		Atp5a1	Nme1	Atp5a1
			Nme1		Impdh2		Atp5h
					Nme2		Impdh2
					Nme1
					Pnp
RNA and mRNA processing	6	Sfrs1			Hnrnpk		Hnrnpc
					Tardbp		Sfrs3
					Pcbp1
Regulation of transcription	7	Ruvbl1		Nup62	Ube2n		Trim28
		Trim28			Tardbp		Ruvbl1
					Cbx3
					Hnrnpab
Embryonic development	5	Sfrs1	Psmc4	Atp5a1	Eno1	Myh9	Eno1
		Eno1	Eno1	Myh9	Atp5a1	Psmc4
Gene expression	16	Trim28	Rps12	Eif3f	Eef1a1		Sfrs3
		Sfrs1		Eif3i	Eif5a		Eif3i
		Ruvbl1			Eef1d		Hnrnpc
					Cbx3		Ruvbl1
					Hnrnpk		Eef1d
					Hnrnpab		Trim28
					Tardbp
					Pcbp1
Cell cycle processes	6	Ruvbl1		Myh9		Krt7	Npm1
						Myh9	Tubb5
							Stmn1
							Ruvbl1
Cell morphogenesis involved in differentiation	4	Trim28		Myh9	Uchl1	Myh9	Stmn1
					Hnrnpab		Trim28
Regulation of cell proliferation	4			Nup62	Nme2	Nme2	Npm1
					Pnp
Regulation of signal transduction	4			Nup62	Ube2n		Npm1
							Hspa5

Ciclopirox olamine (CPX) > retinoic acid (RA): Proteins which were more than 2-fold higher expressed in CPX-treated cells compared to RA-treated cells; CPX < RA: Proteins which were more than 2-fold higher expressed in RA-treated cells compared to CPX-treated cells; CPX > c: Proteins which were more than 2-fold higher expressed in CPX-treated cells compared to control; CPX < c: Proteins which were more than 2-fold higher expressed in control compared to CPX-treated cells; RA > c: Proteins which were more than 2-fold higher expressed in RA-treated cells compared to control; RA < c: Proteins which were more than 2-fold higher expressed in control compared to RA-treated cells.