Lung organoids for preclinical evaluation of stem cell therapies: Opportunities, evidence, and translational challenges

doi:10.4252/wjsc.125409

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. Sep 26, 2026; 18(9): 125409
Published online Sep 26, 2026. doi: 10.4252/wjsc.125409

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Figure 2 Strategies for lung organoid construction and disease modeling. This figure presents a proposed conceptual workflow for generating lung organoids from different stem cell sources and their application in modeling pulmonary diseases. 3D: Three-dimensional; AT2: Alveolar type 2; αSMA: Alpha-smooth muscle actin; COL1A1: Collagen type 1 alpha 1; COPD: Chronic obstructive pulmonary disease.

Citation: Yang LY, Xing YF, Chen JY, Cao ZM, Ye H. Lung organoids for preclinical evaluation of stem cell therapies: Opportunities, evidence, and translational challenges. World J Stem Cells 2026; 18(9): 125409
URL: https://www.wjgnet.com/1948-0210/full/v18/i9/125409.htm
DOI: https://dx.doi.org/10.4252/wjsc.125409

Yang LY, Xing YF, Chen JY, Cao ZM, Ye H. Lung organoids for preclinical evaluation of stem cell therapies: Opportunities, evidence, and translational challenges. World J Stem Cells 2026; 18(9): 125409 [DOI: 10.4252/wjsc.125409]

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