MED12 mutation activates Notch signaling to enhance cancer stemness and suppress CD8+ T cell cytotoxicity in lung cancer

doi:10.4252/wjsc.124540

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. Sep 26, 2026; 18(9): 124540
Published online Sep 26, 2026. doi: 10.4252/wjsc.124540

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Figure 8 Graphic abstract. Dashed arrows indicate functionally associated pathways observed in the NCI-H322 cell model. Definitive causal attribution of Notch activation to the mediator complex subunit 12 mutation requires further isogenic validation. MED12: Mediator complex subunit 12; PD-1: Programmed cell death 1; IFN: Interferon; TNF: Tumor necrosis factor; PD-L1: Programmed death ligand-1; GzmB: Granzyme B.

Citation: Yang Y, Zhong JL, Liu JY. MED12 mutation activates Notch signaling to enhance cancer stemness and suppress CD8+ T cell cytotoxicity in lung cancer. World J Stem Cells 2026; 18(9): 124540
URL: https://www.wjgnet.com/1948-0210/full/v18/i9/124540.htm
DOI: https://dx.doi.org/10.4252/wjsc.124540

Yang Y, Zhong JL, Liu JY. MED12 mutation activates Notch signaling to enhance cancer stemness and suppress CD8+ T cell cytotoxicity in lung cancer. World J Stem Cells 2026; 18(9): 124540 [DOI: 10.4252/wjsc.124540]

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