MED12 mutation activates Notch signaling to enhance cancer stemness and suppress CD8+ T cell cytotoxicity in lung cancer

doi:10.4252/wjsc.124540

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. Sep 26, 2026; 18(9): 124540
Published online Sep 26, 2026. doi: 10.4252/wjsc.124540

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Figure 1 Enrichment analysis of mediator complex subunit 12-associated genes was performed based on The Cancer Genome Atlas database. A: Venn diagram showing the overlapping genes positively correlated with mediator complex subunit 12 expression in lung adenocarcinoma and lung squamous cell carcinoma; B-D: Bubble plot of Gene Ontology enrichment analysis of the overlapping genes, including cellular component (B), molecular function (C), and biological process (D) enrichment; E: Bubble plot of Kyoto Encyclopedia of Genes and Genomes enrichment analysis of the overlapping genes. LUSC: Lung squamous cell carcinoma; LUAD: Lung adenocarcinoma.

Citation: Yang Y, Zhong JL, Liu JY. MED12 mutation activates Notch signaling to enhance cancer stemness and suppress CD8+ T cell cytotoxicity in lung cancer. World J Stem Cells 2026; 18(9): 124540
URL: https://www.wjgnet.com/1948-0210/full/v18/i9/124540.htm
DOI: https://dx.doi.org/10.4252/wjsc.124540

Yang Y, Zhong JL, Liu JY. MED12 mutation activates Notch signaling to enhance cancer stemness and suppress CD8+ T cell cytotoxicity in lung cancer. World J Stem Cells 2026; 18(9): 124540 [DOI: 10.4252/wjsc.124540]

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