Mesenchymal stem cell transplantation for severe acute pancreatitis-associated lung injury: A meta-analysis of animal studies

Table 2 General characteristics of the included studies

Ref.	Country	Animals	SAP modeling	Sample size (T/C)	Type of stem cells	Route of transplantation	Number of stem cells transplanted	Control protocol	Duration of transplantation	Follow-up duration	Outcome measures
Yu and Song[7], 2022	China	SD rats (200 g)	Injection of 3% sodium taurocholate (1 mL/kg) into the biliopancreatic duct	6/6	BMSCs	Tail vein	1 × 107/rat	PBS	6 hours	72 hours	a, b, e, h, k
Li et al[31], 2020	China	SD rats (200-240 g)	Injection of 4% sodium taurocholate (1 mL/kg) into the biliopancreatic duct	12/12	PMSCs	Tail vein	1 × 107/kg	PBS	6 hours	12 hours, 24 hours	a, b, c, d, e, g, h, j, k
Song et al[32], 2019	China	SD rats (150-200 g)	Injection of 3% sodium taurocholate (1 mL/kg) into the biliopancreatic duct	6/6	BMSCs	Tail vein	1 × 107/kg	PBS	12 hours	72 hours	a, b, d, f, i, k
Yu et al[33], 2017	China	SD rats (180-220 g)	Injection of 1.5% sodium deoxycholate (1 mL/kg) into the biliopancreatic duct	10/10	BMSCs	Tail vein	3 × 106/kg	Blank	0	7 days	c
Chen et al[34], 2016	China	SD rats (200-250 g)	Injection of 4% sodium taurocholate (1 mL/kg) into the biliopancreatic duct	10/10	BMSCs	Tail vein	NR	NS	24 hours	24 hours	a, b, e, g, j
Zhao et al[35], 2016	China	SD rats (200-250 g)	Injection of 3% sodium taurocholate (1 mL/kg) into the biliopancreatic duct	10/10	BMSCs	Tail vein	(5-7) × 107/rat	PBS	24 hours	72 hours	a, g, j
Yang et al[36], 2013	China	SD rats (250-280 g)	Injection of 5% sodium taurocholate (1 mL/kg) into the biliopancreatic duct	12/12	UCMSCs	Tail vein	5 × 106/kg	NS	0, 1 hour, 6 hours, 12 hours	48 hours	a, b, e, k
Sheng et al[37], 2012	China	SD rats (200-250 g)	Injection of 5% sodium taurocholate (1 mL/kg) into the biliopancreatic duct	36/32	BMSCs	Tail vein	1 × 107/kg	NS	1 hours	3 hours, 6 hours, 12 hours, 24 hours	b, c, e, h, k
Wu et al[26], 2012	China	SD rats (200-230 g)	Injection of 5% sodium taurocholate (1 mL/kg) into the biliopancreatic duct	20/20	BMSCs	Femoral vein	(0.5-1) × 104/kg	Medium	1 hour	6 hours, 12 hours	a, b, c, e, h, k
Wang et al[12], 2012	China	SD rats (250-300 g)	Injection of 5% sodium taurocholate (1 mL/kg) into the biliopancreatic duct	25/25	BMSCs	Tail vein	1 × 106/rat	Medium	2 hours	1 hour, 3 hours, 6 hours, 12 hours, 24 hours	c, d, g, k
Li et al[38], 2011	China	SD rats (260-280 g)	Injection of 5% sodium taurocholate (1 mL/kg) into the biliopancreatic duct	20/20	BMSCs	Tail vein	2 × 105/kg	NS	0	12 hours	b, c, e, g
Li et al[39], 2011	China	SD rats (180-200 g)	Injection of 5% sodium taurocholate (1 mL/kg) into the biliopancreatic duct	30/30	BMSCs	Tail vein	1 × 107/kg	NS	0	3 hours, 6 hours, 12 hours	b, c, f, k
Lu et al[40], 2011	China	SD rats	Two intraperitoneal injections of L-arginine (2 g/kg)	48/48	BMSCs	Femoral vein	NR	Blank	6 hours	12 hours, 24 hours, 48 hours, 72 hours	d

a: Pancreatic histopathological score; b: Lung histopathological score; c: Lung wet/dry weight ratio; d: Lung myeloperoxidase level; e: Serum tumor necrosis factor-α (TNF-α) level; f: Lung TNF-α level; g: Lung TNF-α mRNA expression; h: Serum interleukin (IL)-1β level; i: Lung IL-1β level; j: Lung IL-1β mRNA expression; k: Serum amylase level. SAP: Severe acute pancreatitis; T: Treatment group; C: Control group; BMSCs: Bone marrow mesenchymal stem cells; PBS: Phosphate buffered saline; PMSCs: Placenta mesenchymal stem cells; NR: Not reported; NS: Normal saline; UCMSCs: Umbilical cord mesenchymal stem cells.