Cancer stem cell plasticity drives therapy resistance in colorectal cancer

doi:10.4252/wjsc.122395

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. Sep 26, 2026; 18(9): 122395
Published online Sep 26, 2026. doi: 10.4252/wjsc.122395

Table 1 Major colorectal cancer stem cell markers and their biological significance

Marker	Biological function	Clinical significance
CD133	Stem cell maintenance, tumor initiation	Associated with poor prognosis and chemoresistance
CD44	Cell adhesion, migration, CSC maintenance	Promotes invasion, metastasis, and therapy resistance
LGR5	Intestinal stem cell marker, Wnt signaling	Drives tumor initiation and regeneration
ALDH1	Detoxification and stem cell metabolism	Correlates with CSC enrichment and poor survival
EpCAM	Cell adhesion and proliferation	Frequently expressed in colorectal CSC populations

CSC: Cancer stem cell; LGR5: Leucine-rich G repeat-containing protein-coupled receptor 5; ALDH1: Aldehyde dehydrogenase 1; EpCAM: Epithelial cell adhesion molecule.

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Citation: Topal U, Saritas AG, Zamur C. Cancer stem cell plasticity drives therapy resistance in colorectal cancer. World J Stem Cells 2026; 18(9): 122395
URL: https://www.wjgnet.com/1948-0210/full/v18/i9/122395.htm
DOI: https://dx.doi.org/10.4252/wjsc.122395

Topal U, Saritas AG, Zamur C. Cancer stem cell plasticity drives therapy resistance in colorectal cancer. World J Stem Cells 2026; 18(9): 122395 [DOI: 10.4252/wjsc.122395]

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