Estrogen receptor 1 regulates ovarian cancer cell stemness and ferroptosis through modulation of the canonical RhoA/ROCK signaling pathway

doi:10.4252/wjsc.121744

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. Sep 26, 2026; 18(9): 121744
Published online Sep 26, 2026. doi: 10.4252/wjsc.121744

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Figure 1 Expression of estrogen receptor 1 in ovarian cancer patients and cell lines. A: Screening of targeted genes associated with ovarian cancer, cell stemness, and ferroptosis using DisGeNET and GeneCards databases; B: GEPIA analysis of estrogen receptor 1 (ESR1) in ovarian cancer patients and health controls; C: Real-time polymerase chain reaction analysis revealed increased ESR1 levels in ovarian cancer cell lines; D: Western blot analysis revealed increased ESR1 levels. Data was expressed as mean ± SD (n = 3). ^aP < 0.01; ^bP < 0.01 vs HOSE group. ESR1: Estrogen receptor 1.

Citation: Zhou S, Cheng X, Zhang JM, Ji J, Ni ZZ, Wang W. Estrogen receptor 1 regulates ovarian cancer cell stemness and ferroptosis through modulation of the canonical RhoA/ROCK signaling pathway. World J Stem Cells 2026; 18(9): 121744
URL: https://www.wjgnet.com/1948-0210/full/v18/i9/121744.htm
DOI: https://dx.doi.org/10.4252/wjsc.121744

Zhou S, Cheng X, Zhang JM, Ji J, Ni ZZ, Wang W. Estrogen receptor 1 regulates ovarian cancer cell stemness and ferroptosis through modulation of the canonical RhoA/ROCK signaling pathway. World J Stem Cells 2026; 18(9): 121744 [DOI: 10.4252/wjsc.121744]

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