Cellular hypoxia reprograms drug response and reveals curcumin-driven cancer stem-cell-associated marker enrichment in oral squamous cell carcinoma

doi:10.4252/wjsc.121991

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. Aug 26, 2026; 18(8): 121991
Published online Aug 26, 2026. doi: 10.4252/wjsc.121991

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Figure 5 Stem cell surface marker expression in OECM-1 cells treated with carboplatin, curcumin, and curcumin combined with carboplatin under normoxic and hypoxic conditions. A: Normoxia; B: Hypoxia. Statistical analysis was performed using two-way ANOVA with Tukey’s multiple comparison test.

Citation: Alharbi HS, Rahman I, AlSheddi MA, Henidi H, Alkahtani MM, Al Makhlafi Z, ElRefai S, Altwaim SA, Alnofaie HS, Salem HM, Omar MG, Alturki A, Talic H, Aladhyani G, Alotaibi F, Basuhail H, Alotaibi R, Alturki N, Alharbi A, Alsultan R, Albassam SK. Cellular hypoxia reprograms drug response and reveals curcumin-driven cancer stem-cell-associated marker enrichment in oral squamous cell carcinoma. World J Stem Cells 2026; 18(8): 121991
URL: https://www.wjgnet.com/1948-0210/full/v18/i8/121991.htm
DOI: https://dx.doi.org/10.4252/wjsc.121991

Alharbi HS, Rahman I, AlSheddi MA, Henidi H, Alkahtani MM, Al Makhlafi Z, ElRefai S, Altwaim SA, Alnofaie HS, Salem HM, Omar MG, Alturki A, Talic H, Aladhyani G, Alotaibi F, Basuhail H, Alotaibi R, Alturki N, Alharbi A, Alsultan R, Albassam SK. Cellular hypoxia reprograms drug response and reveals curcumin-driven cancer stem-cell-associated marker enrichment in oral squamous cell carcinoma. World J Stem Cells 2026; 18(8): 121991 [DOI: 10.4252/wjsc.121991]

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